Hime Shiraki appears to have it all: an angelic voice, an innocent personality, and an adorable face that enamors all onlookers. However, her cuteness is all a lie—it is purely an act to achieve her self-centered goal of marrying a rich suitor. Though she often plays up her innocence to gain favor from those around her, Hime's facade does not absolve her of responsibility when an accident leaves Mai Koshiba injured. Learning that Mai is the manager of Café Liebe—a cafe themed as an all-girls academy—Hime is coerced into taking up a part-time position until Mai recovers. However, Hime's facade cannot cover up her shortcomings at being a waitress, earning her the ire of one of her coworkers, Mitsuki Yano, the elegant onee-sama who often berates Hime over her mistakes. As Hime struggles to adjust to her new job in addition to Mitsuki's unrelenting hostility, her real personality begins seeping through the cracks.

Not much is notable about the lecherous Ataru Moroboshi, but his extraordinary bad luck sticks out like the horns in an alien's head. When Earth is threatened by a fleet of alien invaders known as the Oni, Ataru is selected to represent humanity in a duel against one of them. It is a stroke of rare luck for Ataru that the duel is in fact a game of tag, and that his opponent is Lum, daughter of the Oni's leader, who places her personal dignity above victory—as Ataru finds out by seizing Lum's bikini top and with it, victory. However, misfortune kicks in again when Lum mistakes Ataru's promise to marry his girlfriend, Shinobu Miyake, as the desire to wed Lum herself, and decides she rather likes the idea. Wielding her influence as an alien princess, she moves in with him. Forced to deal with the consequences of his womanizing ways, Ataru must balance his crumbling relationship with Shinobu while keeping Lum happy, all the while flirting with every woman he meets.

After witnessing the death of her family at the hands of bandits, Unchou Kan'u has devoted her life to protecting the innocent by exterminating any group of bandits she comes across. Over time, Kan'u's deeds become famous throughout the land—even if she herself remains unknown. During her travels, she runs across a young girl, Chouhi Yokutoku, whose parents suffered a similar fate as Kan'u's. Finding companionship through their similar pasts, the two girls take a vow of sisterhood and continue to wander the land, determined to bring peace to wherever their journey takes them. During Kan'u and Chouhi's journey, they meet and travel with several people who are sympathetic to their cause, such as the noble Chouun Shiryuu, the headstrong Bachou Mouki, and the calculating Shokatsuryou Koumei. From problems with local lords to groups of ravaging bandits, Kan'u and her friends do what they can to make life a little easier for those in need, wherever they may be.

Wakaba Kohashi, a sheltered rich girl, dreams of becoming a fashionable and trendy gyaru because she admires their outgoing and carefree nature. With this goal in mind, Wakaba begins the school year hoping to make her high school debut as a gyaru. On the first day of class, she meets the pure Moeko Tokita, the serious Nao Mashiba, and the eccentric Mao Kurokawa, and the four of them quickly become friends as they learn about and imitate each other's lifestyles. Wakaba*Girl follows the adventures of these four friends while they experience events like school festivals, waterpark trips, and gym class tests. Along the way, Wakaba discovers what it is like to live as a regular student while Nao, Moeka, and Mao catch a glimpse into the life of a rich family. With never a dull moment in their lives, the four girls make sure to live each day to the fullest.