After witnessing the death of her family at the hands of bandits, Unchou Kan'u has devoted her life to protecting the innocent by exterminating any group of bandits she comes across. Over time, Kan'u's deeds become famous throughout the land—even if she herself remains unknown. During her travels, she runs across a young girl, Chouhi Yokutoku, whose parents suffered a similar fate as Kan'u's. Finding companionship through their similar pasts, the two girls take a vow of sisterhood and continue to wander the land, determined to bring peace to wherever their journey takes them. During Kan'u and Chouhi's journey, they meet and travel with several people who are sympathetic to their cause, such as the noble Chouun Shiryuu, the headstrong Bachou Mouki, and the calculating Shokatsuryou Koumei. From problems with local lords to groups of ravaging bandits, Kan'u and her friends do what they can to make life a little easier for those in need, wherever they may be.

After receiving a flyer from Maina Ichii—a member of the idol group ChamJam—and seeing her perform at a local concert, Eripiyo falls in love with Maina and decides to devote her life to supporting the shy and reserved rising star. Eripiyo's charismatic presence and iconic red tracksuit soon give her recognition as Maina's one and only unrivaled fan. Whether it be a performance or a small fan gathering in the middle of nowhere, Eripiyo is guaranteed to be at every event Maina participates in. Not even an injury or Maina's seemingly cold attitude toward her can stop Eripiyo from pursuing her dream of seeing her beloved idol perform at the world-famous arena Budoukan.

In a world inhabited by people only a few inches tall, young women Hakumei and Mikochi live together in a house built into a tree. Hakumei is an energetic and tomboyish carpenter, while Mikochi is a feminine and calm tailor. Despite their differences, they get along well and spend their days having fun living their lives in the woods. The two of them spend their time working, going on sightseeing adventures, and taking shopping trips into Tsumiki Marketplace by the ocean. They make many friends along the way, be they sentient woodland creatures like Iwashi the Weasel or fellow miniature people such as the songstress Konju and the inventor Sen. Hakumei to Mikochi is a relaxing look into the day-to-day lives of its titular characters as they explore and interact with their tiny world which seems to be straight out of a fairy tale.

The story takes place during a conflict between the Krakozhia Dukedom and the Grania Republic. In the midst of the fighting, a savior appears to the Krakozhia Dukedom, and it is a high school student named Yano Souhei. Two female soldiers, First Lieutenant Ruto and Second Lieutenant Haruka, appear in tanks to intrude on Souhei's everyday life, followed by the enemy soldier Shachirofu, all of whom use firearms without hesitation at his house. (Source: ANN)