Fuutarou Uesugi's efforts as the Nakano quintuplets' private tutor are finally paying off. The academic performances of the five sisters are steadily improving, and they are each closer than ever to achieving their respective dreams. However, it appears that Fuutarou has become more than a teacher for the girls, who urge him to sort out his feelings. The undecided young man promises to make a decision by the end of the school festival. However, Fuutarou's task will not be easy, as the Nakano sisters pull out all the stops to win his heart before it is too late.

After rescuing his former classmates from the perils of a labyrinth—a mythical place that grants a divine magic to whosoever triumphs over its trials—Nagumo Hajime emerges victorious, while the new heroes of the fantasy world Tortus must face their first major failure. Together with his traveling companions and the new team member Kaori Shirasaki, Nagumo resumes his journey to conquer all labyrinths and eventually return to his original world. Meanwhile, the heroes from Earth try learning from their mistakes and prepare for the demon army's invasion. As the final confrontation looms closer, new and old enemies start setting their evil plans in motion. Once more, Nagumo must prove that he can prevail against the most formidable opponents, all while protecting the ones he holds closest to his heart.

Thrown into solitary confinement after a daring rescue attempt, Jolyne Kuujou fights to uncover the sinister plot of Whitesnake, an enemy Stand whose mysterious wielder remains unknown to her. Whitesnake's user is actually Enrico Pucci, priest and chaplain of Green Dolphin Street Prison. Pucci shares a deep connection with a villain who once plagued the Joestar bloodline, making his feud with Jolyne and her father, Joutarou, a personal one. Intent on executing the master plan of his deceased friend, Pucci uses the prison and its inmates to fulfill his nefarious schemes. Assisted by fellow prisoners, like Ermes Costello and Foo Fighters, Jolyne battles several enemy Stand users. As the ramifications of Pucci's plot spread beyond the confines of the prison and begin to threaten the rest of the world, Jolyne embraces her family lineage and risks her life to put an end to evil.

Yuusuke Yotsuya has always disliked Tokyo, but he especially hates the people who live in it. He would rather thrive in a virtual world than try to get along with those around him. At the end of one school day, he sees the popular athlete Iu Shindou talking to Kusue Hakozaki, who spends less time in school due to illness. But when he looks away from the two and back again, they have seemingly disappeared. Mere moments later, Yotsuya enters a state of free-fall, and the world begins to change around him. Dropping into a large pool of water, the first thing he sees when he comes to his senses is an assortment of enormous monsters. He soon finds out that he has been brought into a game world by Shindou and Hakozaki and that he must complete a quest within 14 days. There is one thing that separates this world from the real world: anyone who dies will be brought back to life in 30 seconds as long as one party member is alive. Tasked with numerous quests that increase in difficulty over time, Yotsuya, Shindou, and Hakozaki attempt to discover the mystery behind the perplexing game world.