Edo-period Japan stands strong and proud, decades after its imminent doom was prophesied. The new shogun, Yoshimune Nobu Tokugawa, encounters an array of traditions that, to her modern judgment, make little sense. An epidemic exclusively rages among men, resulting in men making up only one-fifth of the population. Still, three thousand young, agile, and beautiful men serve in the Oooku—the shogun's Inner Chambers. To unearth the origins of the existing hierarchy where women head their families and govern the nation, Nobu reviews the chronicles of the odd disease. Customs and traditions have changed to accommodate for the plague; these new laws dictate the current culture and reflect the cruel story of the first female shogun, Iemitsu Tokugawa. Most notably, these customs seem to lead back to the moment a young monk, Arikoto Madenokoji, must abandon his way of life and devote his remaining days to the shogun and her Oooku.

Seeing everyone else enjoying their youth, socially anxious Renako Amaori is dead set on becoming an extroverted girl. Despite her reclusive past, she changes her appearance, practices conversation, and enrolls in a high school free of anyone that would know her. While she is quickly able to befriend the famous model Mai Ouzuka, after Renako joins her friend group, she realizes pretending to be a completely different person is no easy feat. Soon, Renako and Mai have a heart-to-heart and share their troubles with each other. After the sincere discussion, Renako truly believes they could become best friends. The very next day, however, the unthinkable happens—Mai confesses her love to Renako! Although Renako is not interested in dating, Mai insists the two begin hanging out alternately as friends and a couple, while figuring out which type of relationship suits them better. Determined to create a blissful friendship, Renako tries her best to convince the stubborn Mai. However, Renako herself might have a change of heart as Mai's advances continue to get bolder.

In the year 2062, Earth finds itself fiercely battling Artemis—an AI which rebelled against humankind following a grand-scale workforce automation project failure years prior. In the hope of winning the war, a group of three highly skilled human warriors is assembled, known as the guardians of humanity. Empress, the last surviving guardian, wakes up alone in an empty research facility. Unable to recall anything from the past except a place called Lighthouse No. 8, she begins to search for answers. It is not long before she discovers an impending threat from Artemis—and she is the sole person who can save the world from destruction.

After assassinating the son of business tycoon Leonard Dawson, Golgo 13 finds himself prey to the CIA and the U.S. Army, whom Dawson has personally hired to kill the assassin. As days pass by, Dawson slowly loses his sanity as he continues to plot every attempt to kill Golgo 13 even without caring about who hired the assassin to kill his son. (Source: ANN)