Though Gundam Plastic Models, better known as Gunpla, exploded in popularity with the release of the anime series Mobile Suit Gundam, their presence faded before resurging with a new purpose. Through the power of Plavsky particles, fans are now able to pit their Gunpla against others in a virtual reality-style battle with the best competing at the annual Gunpla World Tournament. Sei Iori, whose father was a once finalist in the competition, dreams of one day conquering the contest himself. However, while Sei is an expert Gunpla builder, he lacks the prowess to effectively fight his creations during actual battle. In comes Reiji, a mysterious boy who is curiously ignorant of society but quickly demonstrates to Sei tremendous ability in Gunpla battles. The two boys decide to combine their strengths in order to sweep the Gunpla World Tournament and take the Gunpla world by storm.

In the year 2314 AD, the world is at peace. Thanks to the sacrifices of Celestial Being and its mobile suit pilots, the people of Earth experience a time of prosperity and unity, enjoying tranquil lives once thought impossible. Celestial Being, an organization once painted as villains by the Earth Sphere Federation, now exists in public perception as a group of heroes, celebrated in film and culture. When an extraterrestrial threat arrives on Earth, threatening the newly acquired calm stasis, Celestial Being springs back into action. Led by ace pilot Setsuna F. Seiei, the Gundam Meisters of the group battle the hostile alien forces, teaming up with old rivals to protect the human race from certain doom.

Earth's once green hills and rich blue oceans have been converted into a desolate wasteland by the relentless onslaught of planet bombs from the expansionist Gamilas Empire. By the year 2199, humankind has retreated to the depths of underground cities to escape the radiation. However, all hope is not lost, as the distant planet Iscandar offers Earth its final salvation: the Cosmo Reverse System, capable of restoring Earth's irradiated surface. In a desperate bid to retrieve this technology from Iscandar, the Earth Defense Force pours its remaining resources into the Yamato—an innovative, state-of-the-art battleship equipped with an infinite energy Wave Motion Engine. From young talent such as Tactical Officer Susumu Kodai to accomplished veterans like Captain Juuzou Okita, the Yamato's crew consists of many individuals, all varying in their experience on the battlefield. But despite their differences, one goal unifies them all: to complete their perilous 168,000 light-year voyage to Iscandar and save humanity from imminent doom.

The boisterous student Kaname Chidori and soldier Sousuke Sagara are enjoying a blissful high school life. However, their peaceful days are disrupted by the threatening terrorist organization Amalgam. Leonard Testarossa, a member of the organization who possesses Whispered, seeks to procure Kaname and her knowledge. Kaname and Sousuke's battle against Amalgam starts right in their own neighborhood, which eventually takes them on a hunt around the world. From the exotic lands of Laos to the barren Mexican coast, Sousuke must gather intelligence to bring down Amalgam. Meanwhile, Kaname's abilities grow, but so does her frustration as her resolve withers. Caught up in an intense game of hide and seek, as well as strategic plots, the pair try to connect and push beyond their own limits.