Megalo Box is an advanced form of boxing where competitors wear metal frames called Gear. When the first ever Megalonia tournament took place, Gearless Joe became its champion and known to all as a legendary fighter. However, soon after, he lost an exhibition match against the second champion and vanished from the public eye. Seven years later, Joe now goes by Nomad and keeps a low profile, occasionally fighting in a few underground matches to get by. He is haunted by hallucinations and relies on a set of painkillers to numb his mind. During a match, Joe wins against an opponent, Chief, who purposefully loses for some extra cash from gamblers. Subsequently, Joe discovers that Chief is from a community of immigrants called the Casa. Chief is gradually trying to make enough money to purchase the land where they live illegally. At first, Joe hesitates to get involved, but eventually decides to lend the Casa a helping hand.

Suzu Urano is a pure and kindhearted girl who loves to draw and keep her head in the clouds. Growing up in the outskirts of Hiroshima with her family, she is more than happy to help with her grandmother's nori business. However, when she becomes of age, Suzu leaves her beloved home to marry Shuusaku Houjou, a man she barely knows. As she integrates into her new husband's household, the homesick bride struggles to adjust to the unfamiliar environment as the war effort extends far beyond its point of no return. When the war reaches Suzu's own backyard and peace gives way to brutality, how will she support herself and those she comes to love along the way? Kono Sekai no Katasumi ni paints a colorful yet haunting depiction of everyday life in the years before and after World War II, showcasing the perseverance and fortitude of ordinary Japanese during one of the darkest periods of modern history.

Self-professed home security guard Mahiro Oyama has not left his home in years, secluding himself in his room playing erotic visual novels. This depraved lifestyle causes his prodigious sister, Mihari, to worry about his well-being. In hopes of solving this problem, she devises a plan to rehabilitate him back to normalcy. The first part of Mihari's plan is to concoct a medicine that changes her brother's biological constitution into a bona fide female, much to Mahiro's vehement dismay. Stuck in this predicament, Mahiro has no choice but to live out his life as a cute girl until the effect wears off—if it ever does.

Kurumi is a beautiful young woman whose beloved boyfriend, Hal, died in a sudden airplane accident. Left heartbroken and gloomy, she isolates herself in a small house. But this soon comes to change when her grandfather requests the help of a humanoid robot named Q01. Taking on the appearance of Hal, Q01 is sent to Kurumi's house in order to save her from her state of despair. As Hal returns day after day and increases his efforts, Kurumi, despite her initial reluctance, slowly begins to open up to him and break free from her depression. But there is more to Hal than meets the eye, and these two will soon learn an unexpected truth about this relationship between a human and an android.