In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him.

Chiyo Sakura is a cheerful high school girl who has fallen head over heels for the oblivious Umetarou Nozaki. Much to Chiyo's confusion, when she confesses to her beloved Nozaki, he hands her an unfamiliar autograph. As it turns out, the stoic teenage boy is actually a respected shoujo manga artist, publishing under the pen name Sakiko Yumeno! A series of misunderstandings leads to Chiyo becoming one of Nozaki's manga assistants. Throughout the hilarious events that ensue, she befriends many of her quirky schoolmates, including her seemingly shameless fellow assistant, Mikoto Mikoshiba, and the Prince of the School, Yuu Kashima. Gekkan Shoujo Nozaki-kun follows Chiyo as she strives to help Nozaki with his manga and hopes that he will eventually notice her feelings.

While most young girls make an effort to show off their feminine charms, Futaba Yoshioka deliberately behaves like she wants to repel anyone who might be attracted to her. Ostracized by her female classmates in middle school for being a little too popular with the boys, she desperately strives to avoid a similar situation in high school by being unnecessarily noisy and graceless. Nevertheless, scattered among Futaba's unpleasant memories are the treasured moments with the boy she had a crush on, Kou Tanaka. Unfortunately, that spell abruptly ended on a sour note when he suddenly stopped attending school and never came back. When Futaba finds out that Kou has returned—with a different last name this time—she can already feel the butterflies in her stomach. However, Kou Mabuchi is not the warm boy that she remembers from her days in middle school; he is now taller, more charismatic and withdrawn—making him far less approachable. Futaba believes that if she returns to her former self, Kou will begin to take notice of her again. But is she prepared to sacrifice her bubble of normalcy and risk losing her friends in the process?

Through their tutor Fuutarou Uesugi's diligent guidance, the Nakano quintuplets' academic performance shows signs of improvement, even if their path to graduation is still rocky. However, as they continue to cause various situations that delay any actual tutoring, Fuutarou becomes increasingly involved with their personal lives, further complicating their relationship with each other. On another note, Fuutarou slowly begins to realize the existence of a possible connection between him and the past he believes to have shared with one of the five girls. With everyone's feelings beginning to develop and overlap, will they be able to keep their bond strictly to that of a teacher and his students—or will it mature into something else entirely?