After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

Moments before Naruto Uzumaki's birth, a huge demon known as the Nine-Tailed Fox attacked Konohagakure, the Hidden Leaf Village, and wreaked havoc. In order to put an end to the demon's rampage, the leader of the village, the Fourth Hokage, sacrificed his life and sealed the monstrous beast inside the newborn Naruto. In the present, Naruto is a hyperactive and knuckle-headed ninja growing up within Konohagakure. Shunned because of the demon inside him, Naruto struggles to find his place in the village. His one burning desire to become the Hokage and be acknowledged by the villagers who despise him. However, while his goal leads him to unbreakable bonds with lifelong friends, it also lands him in the crosshairs of many deadly foes.

Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

It has been two and a half years since Naruto Uzumaki left Konohagakure, the Hidden Leaf Village, for intense training following events which fueled his desire to be stronger. Now Akatsuki, the mysterious organization of elite rogue ninja, is closing in on their grand plan which may threaten the safety of the entire shinobi world. Although Naruto is older and sinister events loom on the horizon, he has changed little in personality—still rambunctious and childish—though he is now far more confident and possesses an even greater determination to protect his friends and home. Come whatever may, Naruto will carry on with the fight for what is important to him, even at the expense of his own body, in the continuation of the saga about the boy who wishes to become Hokage.