Kazuya Kinoshita is a 20-year-old college student who has a wonderful girlfriend: the bright and sunny Mami Nanami. But suddenly, he doesn't. Without warning, Mami breaks up with him, leaving him utterly heartbroken and lonely. Seeking to soothe the pain, he hires a rental girlfriend through an online app. His partner is Chizuru Mizuhara, who through her unparalleled beauty and cute demeanor, manages to gain Kazuya's affection. But after reading similar experiences other customers had had with Chizuru, Kazuya believes her warm smile and caring personality were all just an act to toy with his heart, and he rates her poorly. Aggravated, Chizuru lambastes him for his shameless hypocrisy, revealing her true pert and hot-tempered self. This one-sided exchange is cut short, however, when Kazuya finds out that his grandmother has collapsed. They dash toward the hospital and find Kazuya's grandmother already in good condition. Baffled by Chizuru's presence, she asks who this girl might be. On impulse, Kazuya promptly declares that they are lovers, forcing Chizuru to play the part. But with Kazuya still hung up on his previous relationship with Mami, how long can this difficult client and reluctant rental girlfriend keep up their act?

To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this could not be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss. Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected.

UA Academy's Class 1-A has been the focus of a substantial amount of public attention due to the multiple villain attacks they have faced over the past school year. This attention has left Class 1-A's rivals, Class 1-B, feeling quite bitter. Desiring to prove their skills, they look forward to the opportunity that has been given to them: a set of mock battles between the students of each class. The classes are split into squads of four, each of which is tasked with capturing the other group members. The winner is the group who first secures all of the opposing team. While this sounds simple, a curveball is thrown into the mix with the inclusion of General Course Student Hitoshi Shinsou, who wishes to transfer into the Hero Course. Despite using his training with Class 1-A's homeroom teacher Shouta Eraserhead Aizawa to prove that he's capable of being a real hero, he is still far behind the others due to his lack of experience. However, Shinsou is determined to overcome this challenge. Thus begins the fiery competition between Class 1-A and 1-B as each tries to prove that they are superior to the other.

Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.