In the distant future, humanity has been driven to near-extinction by giant beasts known as Klaxosaurs, forcing the surviving humans to take refuge in massive fortress cities called Plantations. Children raised here are trained to pilot giant mechas known as FranXX—the only weapons known to be effective against the Klaxosaurs—in boy-girl pairs. Bred for the sole purpose of piloting these machines, these children know nothing of the outside world and are only able to prove their existence by defending their race. Hiro, an aspiring FranXX pilot, has lost his motivation and self-confidence after failing an aptitude test. Skipping out on his class' graduation ceremony, Hiro retreats to a forest lake, where he encounters a mysterious girl with two horns growing out of her head. She introduces herself by her codename Zero Two, which is known to belong to an infamous FranXX pilot known as the Partner Killer. Before Hiro can digest the encounter, the Plantation is rocked by a sudden Klaxosaur attack. Zero Two engages the creature in her FranXX, but it is heavily damaged in the skirmish and crashes near Hiro. Finding her partner dead, Zero Two invites Hiro to pilot the mecha with her, and the duo easily defeats the Klaxosaur in the ensuing fight. With a new partner by his side, Hiro has been given a chance at redemption for his past failures, but at what cost?

Crime is timeless. By the year 2071, humanity has expanded across the galaxy, filling the surface of other planets with settlements like those on Earth. These new societies are plagued by murder, drug use, and theft, and intergalactic outlaws are hunted by a growing number of tough bounty hunters. Spike Spiegel and Jet Black pursue criminals throughout space to make a humble living. Beneath his goofy and aloof demeanor, Spike is haunted by the weight of his violent past. Meanwhile, Jet manages his own troubled memories while taking care of Spike and the Bebop, their ship. The duo is joined by the beautiful con artist Faye Valentine, odd child Edward Wong Hau Pepelu Tivrusky IV, and Ein, a bioengineered Welsh Corgi. While developing bonds and working to catch a colorful cast of criminals, the Bebop crew's lives are disrupted by a menace from Spike's past. As a rival's maniacal plot continues to unravel, Spike must choose between life with his newfound family or revenge for his old wounds.

Simon and Kamina were born and raised in a deep, underground village, hidden from the fabled surface. Kamina is a free-spirited loose cannon bent on making a name for himself, while Simon is a timid young boy with no real aspirations. One day while excavating the earth, Simon stumbles upon a mysterious object that turns out to be the ignition key to an ancient artifact of war, which the duo dubs Lagann. Using their new weapon, Simon and Kamina fend off a surprise attack from the surface with the help of Yoko Littner, a hot-blooded redhead wielding a massive gun who wanders the world above. In the aftermath of the battle, the sky is now in plain view, prompting Simon and Kamina to set off on a journey alongside Yoko to explore the wastelands of the surface. Soon, they join the fight against the Beastmen, humanoid creatures that terrorize the remnants of humanity in powerful robots called Gunmen. Although they face some challenges and setbacks, the trio bravely fights these new enemies alongside other survivors to reclaim the surface, while slowly unraveling a galaxy-sized mystery.

Five years after winning the World Martial Arts tournament, Gokuu is now living a peaceful life with his wife and son. This changes, however, with the arrival of a mysterious enemy named Raditz who presents himself as Gokuu's long-lost brother. He reveals that Gokuu is a descendant of the once powerful but now virtually extinct Saiyan race, whose homeworld was annihilated. When he was sent to Earth as a baby, Gokuu's sole purpose was to conquer and destroy the planet; but after suffering amnesia from a head injury, his violent and savage nature changed, and instead was raised as a kind and well-mannered boy, now fighting to protect others. With his failed attempt at forcibly recruiting Gokuu as an ally, Raditz warns Gokuu's friends of a new threat that's rapidly approaching Earth—one that could plunge Earth into an intergalactic conflict and cause the heavens themselves to shake. A war will soon be fought over the seven mystical Dragon Balls, magic objects that can grant any wish. Only the strongest will survive.