There exist few humans in this world with the ability to manipulate their souls to form powerful weapons. Dubbed Blazers, these people study and train at the prestigious Hagun Academy to become Mage-Knights; among the students is so-called failure Ikki Kurogane, the sole F-rated Blazer. However, when the worst student in the academy sees Stella Vermillion, an A-ranked Blazer who also happens to be a princess, naked, she challenges him to a duel with dire stakes—the loser becomes the slave of the winner. There's no possible way that Stella can lose, right? As he tries to prove his strength to a world that believes him to be the weakest, Ikki gains new friends, wisdom, and experience.

There is a tower that summons chosen people called Regulars with the promise of granting their deepest desires. Whether it be wealth, fame, authority, or something that surpasses them all—everything awaits those who reach the top. Twenty-Fifth Bam is a boy who had only known a dark cave, a dirty cloth, and an unreachable light his entire life. So when a girl named Rachel came to him through the light, his entire world changed. Becoming close friends with Rachel, he learned various things about the outside world from her. But when Rachel says she must leave him to climb the Tower, his world shatters around him. Vowing to follow after her no matter what it takes, he sets his sight on the tower, and a miracle occurs. Thus begins the journey of Bam, a young boy who was not chosen by the Tower but opened its gates by himself. They call his kind Irregulars—beings that have shaken the very foundation of the Tower each time they set foot inside it.

Mirai Kuriyama is the sole survivor of a clan of Spirit World warriors with the power to employ their blood as weapons. As such, Mirai is tasked with hunting down and killing youmu—creatures said to be the manifestation of negative human emotions. One day, while deep in thought on the school roof, Mirai comes across Akihito Kanbara, a rare half-breed of youmu in human form. In a panicked state, she plunges her blood saber into him only to realize that he's an immortal being. From then on, the two form an impromptu friendship that revolves around Mirai constantly trying to kill Akihito, in an effort to boost her own wavering confidence as a Spirit World warrior. Eventually, Akihito also manages to convince her to join the Literary Club, which houses two other powerful Spirit World warriors, Hiroomi and Mitsuki Nase. As the group's bond strengthens, however, so does the tenacity of the youmu around them. Their misadventures will soon turn into a fight for survival as the inevitable release of the most powerful youmu, Beyond the Boundary, approaches.

Seven years after the defeat of Majin Buu, Earth is at peace, and its people live free from any dangers lurking in the universe. However, this peace is short-lived; a sleeping threat awakens in the dark reaches of the galaxy: Beerus, the ruthless God of Destruction. Disturbed by a prophecy that he will be defeated by a Super Saiyan God, Beerus and his angelic attendant Whis search the universe for this mysterious being. Before long, they reach Earth and encounter Gokuu Son, one of the planet's mightiest warriors, and his powerful friends.