The seemingly unimpressive Saitama has a rather unique hobby: being a hero. In order to pursue his childhood dream, Saitama relentlessly trained for three years, losing all of his hair in the process. Now, Saitama is so powerful, he can defeat any enemy with just one punch. However, having no one capable of matching his strength has led Saitama to an unexpected problem—he is no longer able to enjoy the thrill of battling and has become quite bored. One day, Saitama catches the attention of 19-year-old cyborg Genos, who witnesses his power and wishes to become Saitama's disciple. Genos proposes that the two join the Hero Association in order to become certified heroes that will be recognized for their positive contributions to society. Saitama, who is shocked that no one knows who he is, quickly agrees. Meeting new allies and taking on new foes, Saitama embarks on a new journey as a member of the Hero Association to experience the excitement of battle he once felt.

Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

Eighth-grader Shigeo Mob Kageyama has tapped into his inner wellspring of psychic prowess at a young age. But the power quickly proves to be a liability when he realizes the potential danger in his skills. Choosing to suppress his power, Mob's only present use for his ability is to impress his longtime crush, Tsubomi, who soon grows bored of the same tricks. In order to effectuate control on his skills, Mob enlists himself under the wing of Arataka Reigen, a con artist claiming to be a psychic, who exploits Mob's powers for pocket change. Now, exorcising evil spirits on command has become a part of Mob's daily, monotonous life. However, the psychic energy he exerts is barely the tip of the iceberg; if his vast potential and unrestrained emotions run berserk, a cataclysmic event that would render him completely unrecognizable will be triggered. The progression toward Mob's explosion is rising and attempting to stop it is futile.

The year is 1868; English nobleman George Joestar and his son Jonathan become indebted to Dario Brando after being rescued from a carriage incident. What the Joestars don't realize, however, is that Dario had no intention of helping them; he believed they were dead and was trying to ransack their belongings. After Dario's death 12 years later, George—hoping to repay his debt—adopts his son, Dio. While he publicly fawns over his new father, Dio secretly plans to steal the Joestar fortune. His first step is to create a divide between George and Jonathan. By constantly outdoing his foster brother, Dio firmly makes his place in the Joestar family. But when Dio pushes Jonathan too far, Jonathan defeats him in a brawl. Years later, the two appear to be close friends to the outside world. But trouble brews again when George falls ill, as Jonathan suspects that Dio is somehow behind the incident—and it appears he has more tricks up his sleeve.