The world of Auldrant is bound by the Score, a series of prophecies from centuries past that dictate the world's future. It is considered an absolute fate that everyone lives by—even people whose actions lead to bloodshed and tears. Using magical abilities known as the Fonic Arts, a war between the nation of Kimlasca-Lanvaldear and the Malkuth Empire is waged in hopes of bringing the Score's foreseen utopia to life. Tales of the Abyss follows Luke von Fabre, who spends his days locked away in his manor after being kidnapped and losing memories as a child. One day, while honing his swordsmanship, a woman named Tear attempts to assassinate his master. Luke defends him, but the clash results in the two being teleported to a distant land. Luke and Tear’s journey back quickly escalates into a quest that will either free the world from the Score's chains or destroy it completely.

In the late 19th century, as the cruel times of the Bakumatsu period came to a close, a new Meiji era marked the age of restoration for Japan. With the war over, its infamous hero Hitokiri Battousai disappeared into thin air, leaving only his legend behind. Years later, a seemingly plain wanderer named Kenshin Himura encounters Kaoru Kamiya, the owner of a struggling local dojo in Tokyo. Kaoru pursues a self-proclaimed Battousai who roams the streets, indiscriminately killing citizens and police officers. Furthermore, the warrior professes to use the Kamiya Kasshin-ryu—a sword style developed by Kaoru's father deeply rooted in the essence of life, not death. Kenshin decides to help Kaoru take down the impostor and restore her father's dojo. Unbeknownst to all, Kenshin is none other than the real warrior whose name still terrifies the people. Although Kaoru eventually learns the truth, his oath to atone for his murderous history by bloodlessly protecting the weak moves her, and she welcomes Kenshin to stay at her dojo. However, Kenshin's ideals are soon challenged by ghosts of the past and enemies of the present.

Hourai is a mysterious island that appears for a limited period once every 50 years. Some say that the isle holds the secret of eternal youth; others believe that it brings disaster to their land. When Inuyasha's group saves a half-demon child from being hunted by a monstrous creature, they learn that her name is Ai and that she fled from Hourai. Surprisingly, the girl is an acquaintance of Inuyasha and begs him to rescue her friends, who are being held prisoner by vicious demons calling themselves the Four War Gods—an enemy Inuyasha remembers well. Upon reaching Hourai, Ai's guests are horrified to discover that only a handful of orphans still inhabit the island and are destined to become sacrifices to increase the Four War Gods' powers. Furthermore, the victims bear their oppressors' enchanted mark, which prevents them from escaping. Defeating the four demons remains Inuyasha's most viable option, but their superiority in strength will require daring initiatives achievable only by the group's combined teamwork.

Second Lieutenant Kei Agemaki, the son of a famous general, has hidden his extreme fear of paranormal beings all his life. However, when he and two others are reassigned to live and work with youkai in the Ministry of Spirit Affairs, he is brought face-to-face with his worst nightmare. Now with the help of the fox spirit Kushimatsu, he and his fellow officers must learn to work alongside youkai maidens—Zakuro, Susukihotaru, Hoozuki, and Bonbori—to solve paranormal cases. Set in the midst of an alternate version of Japanese Westernization, Otome Youkai Zakuro explores the clashes and unions that can occur when east meets west, local meets foreign, and women meet men. The unusual alliance of the youkai maidens and human officers must learn to work together in a world that is changing around them.