Despite occasional setbacks, Operation Strix has remained on track to extract sensitive information from the enigmatic politician Donovan Desmond. To this end, spy Loid Forger has managed to maintain his pretend family consisting of his telepathic daughter, Anya; assassin wife, Yor; and their clairvoyant dog, Bond. Still the only one aware of everyone's true identities, Anya tries to sustain the family's cohesion while working to befriend Donovan's son Damian, her Eden Academy classmate. However, Anya's efforts instead earn her another Tonitrus Bolt, bringing her closer to getting expelled and jeopardizing the operation's success. Hearing the news, Loid faints from shock. In his unconsciousness, he reminisces about his tragic past and his journey to becoming a spy. Realizing what Operation Strix means to him and the world, Loid finds renewed motivation. Although they each work toward their own covert goals, the Forgers continue to cherish their chaotic yet blissful family life.

Oosawa Maria is a Japanese photographer currently working in Shanghai, China. Along with her partner Mino, she searches for potential newsworthy stories throughout the city. When strange events occur at a local festival, Maria and Mino immediately investigate. Quickly, the two are immersed in a battle between unknown masked men and a strange, white-haired woman. Just when Maria is about to be caught in the crossfire, an old friend by the name of Canaan appears and helps Maria escape. But a sinister plot over a deadly virus soon develops, and Canaan learns she must confront her past if she wants any chance at stopping the perpetrator and saving her friends.

Bestowed with magic from God, witches worked to guide humanity toward progress, garnering adoration and fear alike from humans. However, times have since changed. With the advancement of scientific knowledge, humans now stand on an equal footing with witches. Determined to weave their own destinies and establish supremacy over the world, the mighty Redia Empire has ordered the extermination of all witches, which may bring the era of magic to an end. Fleeing from the decree, the famed witch Chloe and her apprentice, Adonis, seek refuge. Hot on their heels, the Empire captures the duo and mercilessly executes Chloe. Agonized by the brutal murder of his master and the callousness of humans, Adonis vows to avenge Chloe by annihilating humanity with the very magic they intend to destroy.

As one of the 12 Seleção that needs to save the country in order to win a game, Akira Takizawa decided to become the King of Japan. With that in mind, after his return from the U.S.A., the remaining Seleção will also need to follow up on their own plans as they strive to outdo each other. Saki Morimi and the other members of the Eden of the East are under suspicion of being terrorists, but they still do everything they can to help Takizawa reach his goal and unravel the secrets of his past, as the last fight between the Seleção begins.