Saenome are tasked with sealing spirits that possess objects and pose a threat to society. Known as tsukumogami, these spirits are generally non-violent, and saenome normally seal them after a simple verbal exchange. Traumatized by a previous deadly encounter with a malevolent spirit, Hyouma Kunato refuses to use peaceful methods and gets into physical confrontations with all tsukumogami that cross paths with him. Deeming this behavior unacceptable for a future clan leader, Hyouma's grandfather, Zouhei, proposes that he starts living with Botan Nagatsuki, a young woman whose family is composed of six tsukumogami—lest he be excommunicated. Determined to track down the spirit that took everything from him, Hyouma reluctantly accepts Zouhei's proposal. As unknown groups of evil spirits begin to jeopardize the balance between worlds, the young man must gain the trust of Botan and overcome his hatred for her mysterious family.

Much like the other students at her school, first-year student Saki Aoi finds herself captivated by the beauty of her senior on the school board, Makoto Hanaoka. While she worries that Hanaoka would be uncomfortable receiving a confession from another girl, Aoi musters up the courage to tell her anyway. However, Hanaoka's response surprises Aoi for a completely different reason—Hanaoka is actually a cross-dressing boy! Fully expecting Aoi to be abhorred by this revelation, Hanaoka is shocked to find that she has no issues with it. Though Hanaoka rejects Aoi's request to go out with her—citing his identity and the fact that he has never fallen in love before—Aoi insists that she will become his first love. Taken aback by Aoi's determination, Hanaoka wonders if he can really fall in love with her if he cannot find it in him to truly love himself first.

City Hunter is a notorious contractor group with the call sign XYZ. No matter the job, they will take it, cleaning up the scum on the streets of Tokyo. The key member of City Hunter is Ryou Saeba; armed with his trusty Colt Python and pinpoint accuracy, he works alongside willful tomboy Kaori Makimura. Together they solve tough cases and tackle the numerous dangers that accompany their trade head-on. However, when he's not out hunting crooks and villains, Ryou finds pleasure in chasing beautiful ladies with only Kaori and her one hundred-ton hammer to keep him in check. From pickpockets and arms dealers to crime syndicates, nothing can stand in the way of Ryou Saeba when he takes aim at his next mission.

First-year high school student Uka Ishimori wants a fresh start. In middle school, Uka was given the nickname Rocky by her peers, being misunderstood as having no emotions when she was actually shy and introverted. As a result, Uka was relentlessly bullied and experienced a lonely, isolated school life. Now, Uka is determined to change. During the first week of school, Uka accidentally gets drenched in lemon soda by her classmate Kai Miura—whose cool personality is the complete opposite of hers. After the incident, Uka is surprised when Kai performs small acts of kindness for her, encouraging her to gradually break out of her shell. Like a lemon soda, bubbly and exciting feelings are beginning to stir.