After her boyfriend breaks up with her for another girl, college student Akane Kinoshita wrestles with a broken heart and the memories he left behind. Loading up Forest of Savior, the MMO they used to play together, she forms a plan to get back at her ex-boyfriend through an in-person event for the game. In the process, she runs into someone unexpected: Akito Yamada, a gaming legend who just happens to be her guildmate. Desperate for support, Akane ropes the asocial Yamada into helping with her scheme and lending her a shoulder to cry on. The differences between Akane and Yamada soon become apparent as they spend time together, yet they cannot help but notice each other's inner qualities. As the two gain more experience with one another in and out of the game, their tentative acquaintance may level up in a way neither expects.

Eccentric and blunt, the walrus Hiroshi Odokawa lives a relatively normal life. He drives a taxi for a living, and there he meets several unique individuals: the jobless Taichi Kabasawa who is dead-set on going viral, the mysterious nurse Miho Shirakawa, the struggling comedic duo Homo Sapiens, and Dobu, a well-known delinquent. But Odokawa's simple way of life is about to be turned upside down. The case of a missing girl the police have been tracking leads back to him, and now both the yakuza and a duo of corrupt cops are on his tail.

Since childhood, Aoba Suzukaze has loved the Fairies Story game series, particularly the character designs. So when she graduates from high school, it is no surprise that she applies to work at Eagle Jump, the company responsible for making her favorite video game. On her first day, she is excited to learn that she will be working on a new installment to the series: Fairies Story 3—and even more so under Kou Yagami, the lead character designer. In their department are people who share the same passion for games. There is Yun Iijima, whose specialty is designing monsters; the shy Hifumi Takimoto, who prefers to communicate through instant messaging; Hajime Shinoda, an animation team member with an impressive figurine collection; Rin Tooyama, the orderly art director; Shizuku Hazuki, the game director who brings her cat to work; and Umiko Ahagon, the short-tempered head programmer. New Game! follows Aoba and the others on their adventure through the ups and downs of game making, from making the perfect character design to fixing all the errors that will inevitably accumulate in the process.

Fumiya Tomozaki is Japan's best player in the online game Attack Families, commonly known as Tackfam. Despite holding such a revered title, a lack of social skills and amiability causes him to fall short in his everyday high school life. Failing to have any friends, he blames the convoluted mechanics and unfair rules of life, forcing him to give up and proclaim himself a bottom-tier character in this game. After a fateful meeting with another top-tier Tackfam player, Fumiya is shocked to discover the player's true identity—Aoi Hinami, a popular, smart, and sociable classmate who is the complete opposite of himself. Aoi, surprised at how inept Fumiya is at everything besides Tackfam, decides to assist him in succeeding in what she calls the greatest game of them all. Through the gruesome ordeals of social interactions and relationships, Fumiya begins to advance tiers in the glorious game of life.