Centuries ago, mankind was slaughtered to near extinction by monstrous humanoid creatures called Titans, forcing humans to hide in fear behind enormous concentric walls. What makes these giants truly terrifying is that their taste for human flesh is not born out of hunger but what appears to be out of pleasure. To ensure their survival, the remnants of humanity began living within defensive barriers, resulting in one hundred years without a single titan encounter. However, that fragile calm is soon shattered when a colossal Titan manages to breach the supposedly impregnable outer wall, reigniting the fight for survival against the man-eating abominations. After witnessing a horrific personal loss at the hands of the invading creatures, Eren Yeager dedicates his life to their eradication by enlisting into the Survey Corps, an elite military unit that combats the merciless humanoids outside the protection of the walls. Eren, his adopted sister Mikasa Ackerman, and his childhood friend Armin Arlert join the brutal war against the Titans and race to discover a way of defeating them before the last walls are breached.

After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.

In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him.