Tomoya Okazaki is a cynical delinquent who lacks ambition as he apathetically labors through high school. During his childhood, a tragedy had caused his father to seek solace in alcoholism and neglect his son. Yet, meaningful human interaction can be a benediction, as Tomoya learns when he meets the enigmatic Nagisa Furukawa. The odd girl offers a gesture of friendship to Tomoya, but he rejects the request, dismissing it as a trivial incident. However, as he soon realizes that he is encountering Nagisa more and more often during school, Tomoya drops his discompassions and befriends the girl. When he learns that Nagisa's dream is to revive the Drama Club, Tomoya decides to shed his detachment from the ordinary pleasures of life and dedicate himself to helping his new friend achieve her ambition. But what starts as a simple friendship may progress into something far more deep, intimate, and life-changing. As the pair face various hardships and afflictions, Tomoya and Nagisa gradually come to terms with the challenges of life.

Tomoya Okazaki is a delinquent who finds life dull and believes he'll never amount to anything. Along with his friend Youhei Sunohara, he skips school and plans to waste his high school days away. One day while walking to school, Tomoya passes a young girl muttering quietly to herself. Without warning she exclaims Anpan! (a popular Japanese food) which catches Tomoya's attention. He soon discovers the girl's name is Nagisa Furukawa and that she exclaims things she likes in order to motivate herself. Nagisa claims they are now friends, but Tomoya walks away passing the encounter off as nothing. However, Tomoya finds he is noticing Nagisa more and more around school. Eventually he concedes and befriends her. Tomoya learns Nagisa has been held back a year due to a severe illness and that her dream is to revive the school's drama club. Claiming he has nothing better to do, he decides to help her achieve this goal along with the help of four other girls. As Tomoya spends more time with the girls, he learns more about them and their problems. As he attempts to help each girl overcome her respective obstacle, he begins to realize life isn't as dull as he once thought.

When a shapeshifting demon with a thirst for human flesh, known as youma, arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a Claymore, a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.

Long ago, a mysterious shrine maiden sealed nature spirits within forest trees to stop them from terrorizing the world. Now, her descendant, a cheerful young princess named Suzu, is prohibited from going outside. However, one day, after sneaking out into an area known as the forbidden zone, Suzu discovers a strange seed which grows into a fun-loving nature spirit. With her new friend, Suzu is eager to explore the outside world that she has been kept from, despite not knowing the dangers of the forbidden zone—or why the seed was being kept there.