With a new school year comes a new crowd of classmates, and for their final year of junior high, aspiring writer Kotarou Azumi and track team member Akane Mizuno end up in the same class. Though initially complete strangers, a few chance encounters stir an innocent desire within their hearts. A yearning gaze, a fluttering heart—the hallmarks of young love slip into their lives as fate brings their paths to a cross. However, though love is patient and love is kind, Kotarou and Akane discover it is not always straightforward. Despite the comfort they find in each other's company, heartache and anxiety come hand in hand with pursuing the feelings in their hearts. With the uncertainty of how the other truly feels as well as the competing affections of those around them, the road ahead is unclear. Even so, under the shining light of a beautiful full moon, Kotarou gathers his courage to ask Akane a single question, one that forever changes their quiet relationship.

A series of unaired comedic shorts released with Blu-ray and DVD boxes of Tsuki ga Kirei.

At the Budokan, an annual event known as the Tsukino Concert puts Tsukino Entertainment Production's best and brightest idol units on the stage. The leaders of idol groups SolidS, SOARA, QUELL, and Growth must compose four unique and distinctive songs for their respective units, which they will perform on the second day of the festival. Composing four new songs proves to be a difficult task for SolidS's leader, Shiki Takamura, as he struggles to find inspiration. Sora Oohara must learn to overcome past mistakes while propelling his unit, SOARA, to the top. Wanting to escape his past stardom, Shuu Izumi is determined to push his unit, QUELL, up to the level of popularity that his previous one had. Growth finds themselves working together with a rival group, ZIX, prior to their debut—something that leader Kouki Etou is reluctant to do. Tsukipro The Animation tells the stories of these four units simultaneously as they go through their daily lives while preparing for the Tsukino Concert.