AD. 2058, on Clayad, the 3rd planet of the Ypserlon system, 43 light years from Earth; aliens suddenly raid the planet. The residents of Clayad must escape the planet. In the confusion of the escape, the children are separated from their parents and board the training spaceship Janous. After many sacrifices, they manage to arrive at the 4th planet, Belwick. However, Belwick is already at war, so the 13 children continue towards Earth on their own. (Source: AnimeNfo, edited)

Following the temporary retreat of the Altana Liberation Army from the Kabuki District, the state of the war has seemingly improved. However, as the Oniwaban, Shinsengumi, and residents of the district combat the army's remnants, Edo's greatest inventor Gengai Hiraga is abducted. Responsible for causing the enemy's withdrawal by rendering their weapons useless, Gengai's nanomachine virus is now at risk of being shut down. Meanwhile, a laser capable of obliterating a planet is activated in Earth's orbit on the Liberation Army's mother ship. Another battle ensues when Shinsuke Takasugi and the rest of the Kiheitai arrive on the vessel to stop the weapon from firing. Forced to fight a war on two fronts, the Yorozuya and their allies must prevail on both sides to save Edo and the rest of the world.

Gintarou is a fox spirit that has been protecting the small Inari temple since the Edo era. Saeki Makoto's family possesses the power to see the gods' agent, but the ability is limited to one living relative at a time. When Makoto's mother passed away while she was still young, Makoto inherited the ability as the sole remaining family member. With the help of fox spirit's power, Makoto and Gintarou help the people of their community, in spite of their many differences. (Source: MangaHelpers, edited)

Gintoki, Shinpachi, and Kagura return as the fun-loving but broke members of the Yorozuya team! Living in an alternate-reality Edo, where swords are prohibited and alien overlords have conquered Japan, they try to thrive on doing whatever work they can get their hands on. However, Shinpachi and Kagura still haven't been paid... Does Gin-chan really spend all that cash playing pachinko? Meanwhile, when Gintoki drunkenly staggers home one night, an alien spaceship crashes nearby. A fatally injured crew member emerges from the ship and gives Gintoki a strange, clock-shaped device, warning him that it is incredibly powerful and must be safeguarded. Mistaking it for his alarm clock, Gintoki proceeds to smash the device the next morning and suddenly discovers that the world outside his apartment has come to a standstill. With Kagura and Shinpachi at his side, he sets off to get the device fixed; though, as usual, nothing is ever that simple for the Yorozuya team. Filled with tongue-in-cheek humor and moments of heartfelt emotion, Gintama's fourth season finds Gintoki and his friends facing both their most hilarious misadventures and most dangerous crises yet.