In a near future, an illness called Cagaster made ​​its appearance. It turns humans into insects. The story begins 30 years after the onset of the illness, in 2125. It follows the adventures of Kidou, a boy who fights insects. (Source: MAL News)

On a warm summer day, a boy heard the sound of bells ringing, as if in celebration, in the mountain near his home. Several years later in that same mountain, the mushishi Ginko encounters a strange girl with weeds growing out of her body. Soon after, Ginko coincidentally runs into the now grown-up boy Yoshiro on his way off the mountain. With Yoshiro's help, Ginko soon begins to uncover who this mysterious girl is and what happened to her. An adaptation of the last arc in the manga, Mushishi Zoku Shou: Suzu no Shizuku follows Ginko's peculiar journey amidst the occult to unravel the mystery behind the enigmatic girl called Kaya and the mountain that has become her home.

Perceived as strange and feared by man, over time the misshapen ones came to be known as Mushi. Although they harbor no ill intentions towards humans, many suffer from the side effects of their existence and strange nature; exploiting the Mushi without understanding them, even unintentionally, can lead to disaster and strife for any involved. Mushishi Zoku Shou continues the story of Mushishi Ginko on his journey to help the visible world to coexist with the Mushi. During his travels, Ginko discovers various gifted individuals—those cursed by circumstance and those maintaining a fragile symbiosis with the Mushi—inevitably confronting the question of whether humanity, talented and tortured alike, can manage the responsibility of the unseen. Moreover, as a Mushishi, Ginko must learn more about these strange beings and decide if he has the right to interfere with the complex relationships between Mushi and mankind.

In 1973, following the ruthless six-year-long Lunar War, the hostile alien species known as the BETA—Beings of Extra Terrestrial origin which are Adversary of the human race—invaded Earth, killing billions and decimating Eurasia. While BETA can be destroyed with conventional weapons, their laser-class is able to wipe out entire aircraft fleets, forcing mankind to develop giant combat suits called Tactical Surface Fighters (TSF) to combat them. When the BETA reach Japan in 1998, military school student and TSF pilot—or eishi—Yui Takamura is ordered to defend Kyoto's last line of defense with her fellow classmates. At the cost of countless human lives and the sacrifice of Yui's friends, the Japanese Imperial Army manages to repel the invaders, leaving destruction in its wake. However, this encounter leaves Yui determined to never again allow something like this to occur. Three years later, now a lieutenant, Yui joins the XFJ project, an Alaska-based Japan-American TSF development program. In an international team composed of the uncooperative Japanese-American test pilot Yuuya Bridges and various eishi from countries lost to the BETA, Yui's task is to help develop the new Japanese TSF Shiranui. Amidst political tensions inherited from the Cold War, Muv-Luv Alternative: Total Eclipse follows Yui's delicate mission and Yuuya's journey to overcome the demons of the past that still haunt him.