At first glance, Ramune may not seem like a professional doctor—he is crass, rude, and often acts halfheartedly. But his true brilliance shines through once his patients pay him a visit: he is able to diagnose and treat all sorts of strange, mysterious diseases that come his way. From a young student whose fingers have turned into chili peppers to a child whose tears are made of condiments, Ramune is able to tap into a kind of innate, otherworldly sensibility that enables him to decipher the roots of their source. But finding the proper cure for these illnesses comes at a valuable price, and money certainly cannot be used to pay it.

Adapted from the popular storybooks of the same name by Yutaka Hara, Kaiketsu Zorori follows the adventures of a scheming fox named Zorori, who is determined to become the King of Mischief with his very own castle and beautiful bride. Although Zorori is notorious for his pranks and tricks, his conniving plots often backfire and end up helping his targets, and despite appearing to be villainous and immoral, he is actually caring and sentimental. Nevertheless, Zorori has the wits, intelligence, and dexterity to always find a solution out of the most hopeless of situations. Travelling with a pair of twin boar bandits, Ishishi and Noshishi, he continues on his journey to make his deceased mother proud.

The elite members of Shuchiin Academy's student council continue their competitive day-to-day antics. Council president Miyuki Shirogane clashes daily against vice-president Kaguya Shinomiya, each fighting tooth and nail to trick the other into confessing their romantic love. Kaguya struggles within the strict confines of her wealthy, uptight family, rebelling against her cold default demeanor as she warms to Shirogane and the rest of her friends. Meanwhile, council treasurer Yuu Ishigami suffers under the weight of his hopeless crush on Tsubame Koyasu, a popular upperclassman who helps to instill a new confidence in him. Miko Iino, the newest student council member, grows closer to the rule-breaking Ishigami while striving to overcome her own authoritarian moral code. As love further blooms at Shuchiin Academy, the student council officers drag their outsider friends into increasingly comedic conflicts.

On the outside, Agastia is a firm specializing in entertainment, well-known for the theme park it operates. However, beneath such an exterior lies a monumental secret: Agastia is one of various highly advanced evil organizations that aim for world domination. Despite its true nature, the company boasts enticements that make it worthwhile to put up with the work environment. Led by its great leader Akashic, Agastia has recently become a frontrunner in reaching its fellow groups' common goal. Working for Agastia's Monster Development Division, Touka Kuroitsu is a researcher who primarily does fieldwork due to the eccentricities of her seniors. Kuroitsu's everyday jobs also include giving abrupt presentations and proposals, meeting ridiculous expectations for monster designs, and accompanying said monsters to face inevitable defeat by Agastia's enemies. Nevertheless, nothing will stop Kuroitsu from doing her best if it means getting the promotion she desires!