With the initiation of the Patrian civil war came the creation of half-beast, half-human soldiers—a development of the outnumbered Northerners in a desperate attempt to counter the overwhelming Southern forces. Able to quickly dominate battlefields and achieve victory with ease, the soldiers' godlike abilities earned them the name Incarnates. However, as the war raged on, the Incarnates encountered a problem involving the beasts inside them that they were unable to rectify by ordinary means. Once the war was over, mysteries and accounts of the Incarnates submitting to the misfortune of their war days surfaced. Aware of the horrors they faced during the war, Special Sergeant Major and former captain of the Incarnates Hank Henriette becomes a Beast Hunter—those who take the lives of Incarnates who have succumbed to the issues they experienced on the battlefields. After witnessing her father, a former Incarnate soldier, meet his end at the hands of one such Beast Hunter, Nancy Schaal Bancroft resolves to hunt the man who took her father's life. However, Nancy's eye-opening encounter with the Beast Hunter influences her to instead seek the reason behind her father's death and the Incarnates' problematic existence in society.

There is no putting it lightly—Tsunayoshi Sawada is just no good. He is clumsy, talentless, and desperately in love with the school idol Kyouko Sasagawa, a girl so completely out of his league. Dubbed Loser Tsuna by his classmates, he seems to be the very personification of failure in the guise of a middle-schooler. Tsuna's boring life takes an extraordinary twist when he encounters the mysterious Reborn, who happens to be a hitman... and shockingly, a baby! Sent from the strongest Mafia family in Italy, Reborn is assigned the daunting mission of preparing the dull middle schooler to succeed the ninth boss of the notorious Vongola family, who is on the brink of retirement. The dull boy has a grueling road ahead, but with the help of his new criminal affiliates and his peculiar home tutor, perhaps even Loser Tsuna can achieve greatness.

Vampires—supernatural beings that feed on the life essence of the unsuspecting at night—have been around for centuries. However, high schooler Karin Maaka is unusual, even among her own kind. Unlike her vampire family, ever since she was a child, Karin has suffered from polycythemia: a rare disorder which causes her to periodically produce excessive amounts of blood. And the more blood she produces, the more anemic and lightheaded she gets, ultimately leading to frequent nosebleeds. Her only solution? Force her excess blood onto random strangers, which surprisingly causes these victims to become livelier and happier than before. With her siblings—Anju, her reserved yet affectionate younger sister, and Ren, her womanizing elder brother—helping her abilities remain a secret by altering the affected humans' memories, no one is the wiser. That is, until Karin's newly transferred classmate, Kenta Usui, finds her behavior suspicious. And to make matters even more complicated, Karin feels her blood reacting unusually to Kenta's presence.

The story takes place in old Tokyo, the Tokyo of August-September 1923 (Taishou 12). At this moment in time, the city is a mixture of extremes...past and present, rich and poor, good and bad. This is a city where we see both horsecarts and motorcars, swords and pistols, lords and businessmen. A wealthy woman from an upper-class family finds herself attracted to a handsome young man, Taka. He and his younger brother seem to be allied, perhaps not entirely willingly, with some of the city's criminal underground (Yakuza). The lady's lovely young maidservant, Sara, meets him too, and a conflict ensues which can only lead to tragedy, passion, and dishonor. But, as events move on, and the days pass, the viewer sees a terrible date coming closer... that unforgettable day of September 1, 1923, at 11:58, when the Great Kanto Earthquake and tidal wave struck Tokyo, causing the death of almost 100,000 people, one of the greatest disasters in human history. (Source: The Technogirls)