Nobita Nobi is an elementary student who hates studying, is bad at sports, and does everything half-heartedly. He is a pushover, unlucky, and fearful of many things. His personality makes him a failure in life, even affecting his progeny. This causes his great-great-grandchild, Sewashi, to take control of the situation. Sewashi travels back in time from the 22nd century to the 20th century to meet Nobita, who is shocked to see him appear out of his drawer alongside a blue robotic cat. The robotic cat calls himself Doraemon, who claims to have been pressured by Sewashi to assist Nobita, with their ultimate goal being to provide Nobita happiness. Frustrated after seeing Nobita's hopeless state, Doraemon decides to go back to the future. However, Sewashi activates a program within Doraemon that prevents him from doing so. Forced to stay, Doraemon helps Nobita using futuristic gadgets through his four-dimensional pocket—a bag containing anything inside it. Can Doraemon bring Nobita happiness and return to the future?

With her ability to read minds, Anya Forger is the only one who knows the true identities of her unconventional family. Her pretend father Loid operates as an elite spy code-named Twilight; her mother Yor kills on demand as the assassin Thorn Princess; and their dog, Bond, possesses the gift of precognition. Although they hide the truth from each other, this pretense of a perfectly ordinary family provides Anya with the genuine love and warmth that she longed for as an orphan. Operation Strix—Loid's special mission to avoid potential war by gathering vital information and getting close to the powerful political figure, Donovan Desmond—is only possible if Anya plays her part right. She can either excel academically and become an Imperial Scholar at her prestigious school or make friends with Donovan's son, Damian. Neither is exactly easy, but with her adventurous attitude, Anya throws herself wholeheartedly into her mission as a Forger—all for the sake of international peace.

Drugs have become the center of conflict in Japan, and crime involving them has been increasing at an alarming rate. Unable to control the chaos, the police department settled on creating a unit—STAND—that would include unique, specialized experts and professionals better suited to handle the pressing issue. Rei Izumi is a novice joining the narcotics investigation unit, assigned the daunting task of recruiting the potential representatives of STAND. While recommended for her moral sense of justice and devotion to police work, Rei also has a unique aspect of her own that may have earned her the job—she has an immunity to many, if not most, kinds of drugs. Eager to seek the possible members of STAND, Rei quickly learns that scouting the different individuals will be more difficult than she expected, as each candidate harbors their own feelings, ideologies, and willingness toward joining the team and regulating drugs as a whole. Her capability as a narcotics officer is also questioned by the many colorful personalities she meets, stirring conflict and unpredictability in Rei's daily life. However, persuading the various contenders for STAND isn't the only obstacle she faces, as becoming involved in the treacherous underworld of drugs, overflowing with deceit and secrecy, will be more hazardous than she ever imagined.

After reminiscing about his late grandmother, Nobita Nobi wishes to see her again and asks Doraemon to return them to the past. Following the wholesome reunion of the two, Nobita's grandmother confesses that she hopes to meet his future bride. Nobita accepts her request out of filial love and quickly scrambles into the time machine as he and Doraemon journey forward in time. However, when the duo warps to Nobita's wedding day, they discover that the future Nobita is missing from the ceremony! Determined to set things right, Doraemon and Nobita embark on a mission to search for Nobita's future self and encourage him to discover the happiness he deserves.