OZ, a virtual world connected to the internet, has become extremely popular worldwide as a spot for people to engage in a large variety of activities, such as playing sports or shopping, through avatars created and customized by the user. OZ also possesses a near impenetrable security due to its strong encryption, ensuring that any personal data transmitted through the networks will be kept safe in order to protect those who use it. Because of its convenient applications, the majority of society has become highly dependent on the simulated reality, even going as far as entrusting the system with bringing back the unmanned asteroid explorer, Arawashi. Kenji Koiso is a 17-year-old math genius and part-time OZ moderator who is invited by his crush Natsuki Shinohara on a summer trip. But unbeknownst to him, this adventure requires him to act as her fiancé. Shortly after arriving at Natsuki's family's estate, which is preparing for her great-grandmother's 90th birthday, he receives a strange, coded message on his cell phone from an unknown sender who challenges him to solve it. Kenji is able to crack the code, but little does he know that his math expertise has just put Earth in great danger.

Shiina Aki is constantly being treated like a girl due to his feminine looks so he decides to move to Tokyo to attend middle school in an attempt to change himself. However, what awaits him in his new home, Sunohara-sou, is the kind-hearted caretaker, Sunohara Ayaka. Along with the three female members of Aki's new middle school's student council, Yukimoto Yuzu, Yamanashi Sumire, and Kazami Yuri. And so begins Aki's new life in Tokyo living with four girls.

The series beings at the home of a young boy named Sho Azuka discovers the magical Bible Superbook that speaks and sends him, his friend Azusa Yamato, and his toy robot Zenmaijikake back in time to the early events of the Old Testament.

Super Sonico is a clutzy, adorable, and well-endowed 18-year old girl. She's a complete sucker for anything cute, especially stray cats, all of which she giddily adopts. However, though Sonico should be enjoying a carefree and simple lifestyle as a young college student, her life is really anything but easy: she must balance being a professional model, working part-time at her grandmother's restaurant, and practicing guitar and performing concerts with her friends Suzu Fujimi and Fuuri Watanuki in their band, First Astronomical Velocity—all while attending college. SoniAni: Super Sonico the Animation follows Sonico as she faces daunting challenges in her search for her place in the world, even when her days are brimming with love and happiness.