As dungeon-like treasure vaults started appearing throughout the land, more and more people began signing up as treasure hunters—risking their lives to obtain the vast riches and ancient relics inside. In the imperial capital of Zebrudia, the top hunter party is the Grieving Souls—a group of six childhood friends led by Krai Andrey, who is thought to be the strongest of them due to having a reputed wide array of skills. However, Krai actually has no special talent. His accomplishments are actually the result of his friends being overpowered. Krai has repeatedly attempted to leave the party out of fear his lack of aptitudes would one day cause his companions' downfall. Nevertheless, everyone around Krai thinks differently, making him feel obligated to remain the group's leader.

During their martial arts training expedition in China, Ranma Saotome and his father Genma suffered an accident, which in turn, afflicted them with a curse—whenever they are doused with cold water, Ranma transforms into a girl, while his father turns into a panda! Only hot water can reverse these changes, but any further contact with cold water opens the can of worms once more. Unfortunately, the trouble does not end there, as Ranma finds out about his betrothal to one of the daughters of Soun Tendou, his father's closest friend. During the families' first meeting, it is decided that Ranma is to be married to Akane, the youngest daughter, a decision that is met with vehement protests from both sides. The two are simply not compatible, yet they are forced to live under one roof. Ranma's status quo further adds to the chaos, leading him to a series of comedic situations and misunderstandings that, in the grand scheme of things, may just be what he needs to work with Akane.

Throughout his youth, unskilled healer Laust was taken advantage of by unscrupulous adventurers. Despite intensive efforts to improve himself, Laust is swindled by the members of Blades of Lightning—the first party that he joins after completing his training—and is eventually banished by its leader Margulus. As the subject of public ridicule, Laust is not hopeful about his future prospects. However, novice adventurer Narsena unexpectedly offers to form a party with him, and he happily accepts. The duo quickly gain fame by conquering uncharted parts of the labyrinth. While there seems to be a reason behind Narsena's hasty proposal, Laust is oblivious to what it could be. Meanwhile, Margulus fails for the second time to slay a poisonous hydra, even after enlisting the help of elite healer Lyra for the quest. Laust soon finds himself being asked to rejoin Blades of Lightning, but it is not as easy as he imagined to move on from his former comrades-in-arms despite his new path and current companion.

In the city of Edoropolis, hundreds of mechanical animals live in harmony alongside each other. However, when Lord Wanko discovers that the shogun's chief advisor, Lord Korn, is plotting to take over the government, he knows that something must be done to preserve the peace. In order to thwart Korn's plans, Wanko forms the Nyankees—an elite ninja team led by the fearless Yattarou, who wields the mystic sword Masamasa. With all this power, the Nyankees seem unstoppable! But Korn's schemes are not the only thing the team has to worry about. Secretly based out of the popular Pizza Cats restaurant, the Nyankees must keep their operations hidden while delivering piping-hot plates of pizza and justice.