Bestowed with magic from God, witches worked to guide humanity toward progress, garnering adoration and fear alike from humans. However, times have since changed. With the advancement of scientific knowledge, humans now stand on an equal footing with witches. Determined to weave their own destinies and establish supremacy over the world, the mighty Redia Empire has ordered the extermination of all witches, which may bring the era of magic to an end. Fleeing from the decree, the famed witch Chloe and her apprentice, Adonis, seek refuge. Hot on their heels, the Empire captures the duo and mercilessly executes Chloe. Agonized by the brutal murder of his master and the callousness of humans, Adonis vows to avenge Chloe by annihilating humanity with the very magic they intend to destroy.

Ever since he published a picture that sparked a wave of online harassment, freelance photographer Kouya Madoka has lost everything: his wife Saeko Yukihira, his confidence, and his courage to photograph people. However, years later, a job offer introduces him to the exhilarating world of Formula 4 (F4). A single fierce battle between the amateur drivers in the junior category of open-wheel car racing becomes enough to make Madoka unable to put his camera down. When Komaki Motors' Haruka Asahina bursts into tears on the track, Madoka manages to capture this vulnerable moment. This photo eventually leads Madoka to an impulsive decision: he will help sponsor both the Komaki team and Haruka himself. But the unreasonable costs of the sport quickly cause Madoka to reassess his ambitions, and he seeks different ways to support the severely underfunded F4 team. Despite the uphill battle, Madoka's determination for Haruka to succeed may be the trigger that can propel the young driver straight to the top.

In the near future, 10 percent of the population will consist of Humanoids—machines with advanced functions and artificial intelligence resembling human personalities, easily recognized by their sideways pupils. These specialized patients likewise require a special doctor. By day, Dr. Hikaru Sudou runs a medical clinic for Humanoids; by night, under the moniker of Moggadeet, he performs illegal procedures and gathers information about his lost mother. Hikaru encounters patients with varying problems unique to this society: a Humanoid struggling with the question of whether she and the source of her backup data are the same person, a teenage Humanoid who cannot improve athletically, and even a robot teddy bear with memories of multiple owners. As the world's technology constantly evolves, newer and more complex questions surrounding humanity arise. With each new advance, it becomes more difficult to define what truly makes one human or Humanoid.

In the middle of the 21st century, powerful individuals with superhuman strength appeared all across the world. These people who wore flashy clothes and performed incredible feats in the name of peace became known as heroes—symbolic figures of the nation they came from. In Japan, 14-year-old middle school student Teru Momijiyama is widely known by her secret identity as Japan's hero, Shy. As a young, timid girl, Shy is a fairly new hero with a lot to learn. She struggles with self-confidence and questions if she is worthy of the hero title. Even though she is unsure of herself, Shy works hard to save people and do the right thing. As new, powerful threats reveal themselves, Shy must cooperate with heroes around the world all while learning what it means to be a hero.