Rem is an ordinary woman in our world but, in the world of dreams, she becomes a dream warrior, defending humanity from the evils there. When dream demons reach the waking world, she fights them with the help of her pets which transform into a tiger and wolf.

By day, Ryu Hayabusa is the owner of a simple shop selling Japanese antiques. By night, he defends New York City as the Dragon Ninja. When the respected Dr. Ned Friedman announces that he has developed a perfect cure for cancer in an extremely bizarre press conference, Ryu knows that something is very wrong. Along with his trusted associates who work for a small newspaper, Ryu sets out to uncover the dark secrets behind Dr. Friedman's supposed miracle cure.

Yato and Yukine have finally mended their relationship as god and Regalia. As a minor and unknown deity, Yato continues to take odd jobs for five yen apiece in hopes of one day having millions of worshippers and his own grand shrine. He has yet to fix Hiyori Iki's loose soul, but she cheerily prepares for high school nonetheless. While things are seemingly back to normal, the complicated history between Yato and Bishamon—goddess of war and warriors—resurfaces. Bishamon holds a mysterious old grudge against Yato, which results in violent clashes between them. To further complicate matters, Bishamon's most trusted Regalia, Kazuma, is indebted to Yato. When lives are on the line, unraveling these secrets is possibly the only way to correct mistakes of the past.

In times of need, if you look in the right place, you just may see a strange telephone number scrawled in red. If you call this number, you will hear a young man introduce himself as the Yato God. Yato is a minor deity and a self-proclaimed Delivery God, who dreams of having millions of worshippers. Without a single shrine dedicated to his name, however, his goals are far from being realized. He spends his days doing odd jobs for five yen apiece, until his weapon partner becomes fed up with her useless master and deserts him. Just as things seem to be looking grim for the god, his fortune changes when a middle school girl, Hiyori Iki, supposedly saves Yato from a car accident, taking the hit for him. Remarkably, she survives, but the event has caused her soul to become loose and hence able to leave her body. Hiyori demands that Yato return her to normal, but upon learning that he needs a new partner to do so, reluctantly agrees to help him find one. And with Hiyori's help, Yato's luck may finally be turning around.