Apprentice mage Chise Hatori is invited to enroll at the College, a prestigious learning institution for sorcerers, to examine and look for a way to remove the curses she bears. Despite the reluctance of her groom, Elias Ainsworth, Chise accepts the proposal, as she believes attending the school might help her minimize her self-sacrificing tendencies. From the get-go, Chise grabs the attention of her classmates and professors alike, who have never seen a mage in action before. However, there is a sinister plot brewing behind the College's back, and the young mage will have to determine who is friend or foe in order to put a stop to it.

Yako Katsuragi is an acclaimed high school detective, who, despite her young age, has solved many cases. In fact, there seems to be no case that she cannot solve, or any culprit that escapes justice. But within the walls of her detective agency lies the secret to her prolific crime-solving skills: the cases are actually solved by her assistant, Neuro Nougami. However, to call Neuro an ordinary man would be incorrect. In reality, he is a demon, who came to the human world in search of the ultimate mystery, having already solved every mystery in the demon world. With Yako as his proxy, he feasts on the negative energy released by humans when they commit crimes. Thus, he promises to help Yako solve the mystery of her father's death. But to do so, he must avoid drawing too much attention to himself, which is why Yako plays the role of the detective. As Yako desperately searches for the truth of her father's death, the unlikely duo continues to solve case after case in order to satisfy Neuro's ravenous appetite.

Seventeen-year-old William Twining takes pride in his lineage as well as his devotion to modern science. When he learns that his family has gone bankrupt, the pompous noble is faced with the reality that he can no longer afford his tuition or the lifestyle he is accustomed to. In a desperate search for valuables in his manor, William discovers a hidden room and accidentally summons the arrogant demon Dantalion, the Grand Duke of Hell. Apparently, Lucifer—the ruler of Hell—has fallen into a deep slumber. In his absence, only the human Elector has power to select a temporary successor, which is the cause of tension among demonkind. Although told that he is the direct descendant of King Solomon and has unshakable authority in the underworld, William refuses to believe it. While denying the existence of magic and the supernatural altogether, the defiant realist fails to recognize that he is at the center of the ongoing battle between Heaven and Hell.

An entire city is destroyed by two monstrous and omnipotent beings. Genzou Kuruma, a scientist but also the leader of a sect wishes to awake God, but first, he needs a special kind of blood for it. His son, Shinichi Kuruma, and a young girl, Ayaka Sanders, possess that blood, and he will do anything to capture them and take their blood for God's Awakening, and so, humanity will be lost. Shinichi, along Ayaka and Tomizoro (Tommy), are escaping from Genzou Kuruma's New Humans (genetically altered humans who can turn into monsters), while Shinichi only wishes for revenge against his father. He, like the other New Humans, has the power to summon different beasts from his body. With this power, he will fight until Genzou Kuruma is killed by his own hands. (Source: ANN)