Death City is home to the famous Death Weapon Meister Academy, a technical academy headed by the Shinigami—Lord Death himself. Its mission: to raise Death Scythes for the Shinigami to wield against the many evils of their fantastical world. These Death Scythes, however, are not made from physical weapons; rather, they are born from human hybrids who have the ability to transform their bodies into Demon Weapons, and only after they have consumed the souls of 99 evil beings and one witch's soul. Soul Eater Evans, a Demon Scythe who only seems to care about what's cool, aims to become a Death Scythe with the help of his straight-laced wielder, or meister, Maka Albarn. The contrasting duo work and study alongside the hot headed Black☆Star and his caring weapon Tsubaki, as well as the Shinigami's own son, Death the Kid, an obsessive-compulsive dual wielder of twin pistols Patty and Liz. Soul Eater follows these students of Shibusen as they take on missions to collect souls and protect the city from the world's threats while working together under the snickering sun to become sounder in mind, body, and soul.

Soul Eater NOT! is a spin-off and side story that takes place one year prior to the events of the original Soul Eater. At the Death Weapon Meister Academy, humans born with the power to transform into weapons and those with the power to wield these weapons (Meisters) train to hone their natural talent. The characters of the main series are enrolled in the Especially Advantaged Talent class, where they train to become warriors of justice capable of defeating what threats prey on innocent lives—or even the entire world. Other students at the DWMA are less talented. Members of the Normally Overcome Target class focus less on being warriors of justice and more on controlling their powers so they don't hurt themselves or anyone around them. Tsugumi Harudori, a new halberd-transforming student, meets Meisters Meme Tatane and Anya Hepburn and quickly grows indecisive about which of the two new friends should be her partner. As they learn to use these powers and settle in, their lives as everyday students will be far from normal.

Hikari Hanazono has always been able to do things that normal people cannot. As a child, she assumed no one could beat her—until she met Kei Takishima. Thinking she would win, Hikari challenged him to a match. But things didn’t go as planned; she lost not once but each time she rechallenged him. From that point on, she has sworn to best Kei at everything, ranging from academics to athletics. To achieve her goal, Hikari enrolls in the same school as Kei—Hakusenkan, a prestigious institute for the wealthy. As a pair, they hold the top two rankings in school and are among seven of the academy's best students in a class known as Special A. While Hikari treats Kei as a rival, she is completely oblivious that he harbors hidden feelings for her. Together, the members of Special A deal with competition, friendship, and just a bit of love.

Lately, shy Manami has been flirting outrageously and sparking vicious cat-fights! Afterwards, she remembers nothing. Can it be that another personality seethes beneath her own? A wild woman who’ll do anything to find trouble? (Source: AniDB)