Something evil is stirring in the shadows of Tokyo... During the spring of his senior year in high school, quiet Tatsuma Hiyuu transfers to Magami Academy in Shinjuku. The mysterious boy's outsider status and his profound skills in martial arts quickly earn him the friendship of class delinquent Kyouichi Houraiji. Through an uncanny connection and a happenstance challenge, he also meets Yuuya Daigo of the wrestling club, the captain of the girls' archery club, Komaki Sakurai, and Aoi Misato, the Student Council President. During their encounter, there is a sudden, harsh disruption of the Ryumyaku (literally Dragon Pulse, otherwise known as Dragon Vein or Dragon Stream), the flow of arcane energy. The surge awakens within the five teenagers a latent power, giving them each a supernatural ability. Enlightened to their newly acquired gifts by Hisui, the young heir of the Kisaragi Clan who maintains his family's antiques shop - as well as their duty to protect Tokyo from Oni (demons) - the Magami students decide to use their power to protect the city from the onslaught of dark forces. Battling the demons alongside Hisui Kisaragi, the five unlikely friends discover that they may have to face a greater threat to Tokyo other than destroying a few malevolent, random monsters. The Ryumyaku had been disrupted by force, from someone invoking the Dark Arts - and that person has a wicked desire to unleash a long-dead evil. Can the teenagers overcome their own fears and flaws to fight against the Dark Arts? And soon they will also have to face their own destinies as they discover their Stars of Fate. This anime is based on a manga, which was based on the Nintendo role-playing video game originally released in 1998.

Onmyoudou magic was once a powerful technique used by the Japanese during the second World War in order for them to gain the upper hand and establish their nation as a formidable force. But Japan was quickly defeated after the revered onmyouji Yakou Tsuchimikado caused the Great Spiritual Disaster, an event which plagues Tokyo to this very day. As a result of this mishap, the Onmyou Agency was established in order to exorcise further spiritual disasters and combat the demons that would make their way into the world. Now, Onmyoudou has become far more modern, simplified, and refined for use in a wide variety of applications such as medicine and technology. However, not everyone is able to utilize the magic, as is the case with Harutora, a member of the Tsuchimikado's branch family. Despite an old promise to protect Natsume, the heir of the Tsuchimikado's main family and Yakou's supposed reincarnation, as her familiar, Harutora has no talent and chooses to live a normal life instead. But when a prominent member of the Onmyou Agency attempts to recreate the same experiment which led to Japan's downfall, he decides to make good on his word and fight by Natsume's side.

The battle against Tendou Kodzunu is over, and the Magami Five begin to look forward to their senior graduation, hopefully planning for their adult futures. However, life in Tokyo is not at peace... The underground assassin group known as the Twelve Heavenly Generals of the Martial Fist begin to move against those protecting the city from demons. Normally rumored to kill criminals that the mundane law was unable to bring to justice, the Martial Fist now set their sights on Tatsuma Hiyuu, Kyouichi Houraiji, Aoi Misato, Komaki Sakurai, Yuuya Daigo, and Hisui Kisaragi. What is the purpose of this cruel turn of events? And who ordered the hit? New threats emerge as others awakened to powers unleashed by the Ryumyaku seek out the Magami kids - and old friends now return as enemies. Destinies will collide as the Stars of Fate begin to merge; Yin and Yang will meet. And soon the shadowy figure pulling the strings will reveal himself, in an effort to raze Tokyo to the ground and awaken the Vessel of the Golden Dragon.

Shizuku Mizutani is apathetic toward her classmates, only caring about her grades. However, her cold view of life begins to change when she meets Haru Yoshida, a violent troublemaker who stopped attending class after getting into a fight early in the school year. He is not much different from her, though—he too understands little about human nature and does not have any friends. Much to Shizuku's surprise, he proclaims that she will be his friend and immediately confesses his feelings toward her upon meeting her. Because of her lack of friends and social interaction, Shizuku has a hard time understanding her relationship with Haru. But slowly, their friendship begins to progress, and she discovers that there is more to Haru than violence. She begins to develop feelings for him, but is unsure what kind of emotions she is experiencing. Together, Shizuku and Haru explore the true nature of their relationship and emotions.