With her ability to read minds, Anya Forger is the only one who knows the true identities of her unconventional family. Her pretend father Loid operates as an elite spy code-named Twilight; her mother Yor kills on demand as the assassin Thorn Princess; and their dog, Bond, possesses the gift of precognition. Although they hide the truth from each other, this pretense of a perfectly ordinary family provides Anya with the genuine love and warmth that she longed for as an orphan. Operation Strix—Loid's special mission to avoid potential war by gathering vital information and getting close to the powerful political figure, Donovan Desmond—is only possible if Anya plays her part right. She can either excel academically and become an Imperial Scholar at her prestigious school or make friends with Donovan's son, Damian. Neither is exactly easy, but with her adventurous attitude, Anya throws herself wholeheartedly into her mission as a Forger—all for the sake of international peace.

In the near future, 10 percent of the population will consist of Humanoids—machines with advanced functions and artificial intelligence resembling human personalities, easily recognized by their sideways pupils. These specialized patients likewise require a special doctor. By day, Dr. Hikaru Sudou runs a medical clinic for Humanoids; by night, under the moniker of Moggadeet, he performs illegal procedures and gathers information about his lost mother. Hikaru encounters patients with varying problems unique to this society: a Humanoid struggling with the question of whether she and the source of her backup data are the same person, a teenage Humanoid who cannot improve athletically, and even a robot teddy bear with memories of multiple owners. As the world's technology constantly evolves, newer and more complex questions surrounding humanity arise. With each new advance, it becomes more difficult to define what truly makes one human or Humanoid.

Having just moved from Tokyo to Hokkaido, high school student Tsubasa Shiki decides to explore the picturesque winter landscape he could never experience in the nation's capital. It only takes a moment for Tsubasa's idealized view of Japan's northernmost prefecture to crumble, as the sheer cold and frigid air quickly overwhelm him. While trying to find the way to his new home, Tsubasa runs into Minami Fuyuki—a talkative and friendly Hokkaido native who, despite the cold, is wearing a short skirt. The girl wastes no time in striking up a conversation, and Tsubasa comes to realize that the winter weather is not all that is too much for him to handle. The next day, Tsubasa is shocked to learn that not only is Fuyuki in his class, but her seat is also right next to his. Swept along by Fuyuki's persistent advances, the young man soon becomes captivated by both life in Hokkaido and the beautiful girl determined to get closer to him. As he deepens his relationship with Fuyuki and meets other fashionable girls from his school, Tsubasa finds out that Hokkaido gals truly are adorable.

In the middle of the 21st century, powerful individuals with superhuman strength appeared all across the world. These people who wore flashy clothes and performed incredible feats in the name of peace became known as heroes—symbolic figures of the nation they came from. In Japan, 14-year-old middle school student Teru Momijiyama is widely known by her secret identity as Japan's hero, Shy. As a young, timid girl, Shy is a fairly new hero with a lot to learn. She struggles with self-confidence and questions if she is worthy of the hero title. Even though she is unsure of herself, Shy works hard to save people and do the right thing. As new, powerful threats reveal themselves, Shy must cooperate with heroes around the world all while learning what it means to be a hero.