After living peaceful days at the Kamiya dojo, Kenshin Himura finds himself at a crucial crossroads, as his vow to never end a life is put to the ultimate test. Following the murder of his former commander, he now has to retread the road of violence and blood to take down Makoto Shishio—the assassin prodigy who calls himself the notorious Battousai's successor. With ambitions to overthrow the Meiji government and establish his dominion in Kyoto, Shishio has meticulously schemed for a decade, building a formidable anti-government military force. Now, Shishio has turned his sights toward recruiting Aoshi Shinomori, a cold-blooded killer and the former leader of the legendary Oniwaban Group warriors. As Kenshin travels through a village abandoned by the government and currently under the iron fist of Shishio's henchmen, he is determined to prevent the country from spiraling back into civil war. He allies with his former rival, Hajime Saitou, forging a fragile partnership in a battle against Shishio's empire that will determine the fate of Japan.

After witnessing his mother's death at a young age, Uryuu Kamihate grew up disillusioned with the gods, dismissing faith in them as utter nonsense. Due to his beliefs, he aims to become a doctor, spending most of his time studying to enter the prestigious Kyoto University. To further his studies, Uryuu searches for a new place to take him in and get away from the noisy environment of the orphanage where he grew up. Chidori Amagami, head priest of the Amagami Shrine, allows him to stay at the Amagami residence. However, Uryuu has to live there with Chidori's three granddaughters—Yae, Yuna, and Asahi—who serve as shrine maidens. Moreover, Chidori has another condition for Uryuu: he has to marry one of the sisters to ensure the shrine's future and one day inherit it. But with Uryuu's goals and outlook naturally clashing against the sisters' beliefs, this already daunting ordeal seems outright impossible.

There is not a single room that Mona Kawai enters where she does not become the center of attention—dealing with this everlasting spotlight is but a fact of her daily life. Mona's absolute confidence in her own charms, however, is shaken when she meets Medaka Kuroiwa, a recent transfer student to her highschool. Unlike all other classmates who constantly fawn over her, Medaka frowns every time they interact. Seeing his disinterest as something to be rectified, Mona pulls out all the stops in the hopes of winning Medaka over, only to be met with one stern face after another. Turns out, Medaka's indifference to Mona stems from his wish to one day become a monk, and hence must leave all worldly desires behind. As the unknowing Mona ramps up her attacks on Medaka, all her antics might lead her into falling for him instead.

The premise of this gag manga spinoff is about three high school students: a young male student, his girlfriend and a third wheel who is a One Piece fanatic. Their names are similar to the Straw Hat Pirates and the group form a fan club dedicated to One Piece. (Source: One Piece Wiki)