Owing to an increasing debt, Kaiji Itou ends up resuming his old lifestyle. One day, while walking on the street, he stumbles upon Yuuji Endou, who is hunting Kaiji due to the money he owes to the Teiai Group. Unaware of this, Kaiji eagerly follows Endou, hoping for a chance to participate in another gamble, but soon finds out the loan shark's real intentions when he is kidnapped. Given that Kaiji is unable to pay off his huge debt, the Teiai Group instead sends him to work in an underground labor camp. He is told that he will have to live in this hell for 15 years, alongside other debtors, until he can earn his freedom. His only hope to put an early end to this nightmare is by saving enough money to be able to go back to the surface for a single day. Once he is there, he plans to obtain the remaining money needed to settle his account by making a high-stakes wager. However, as many temptations threaten his scarce income, Kaiji may have to resort to gambling sooner than he had expected.

After one of his coworkers fails to repay a debt, apathetic bum Kaiji Itou is pressured by loan sharks to settle the large sum of cash. Since Kaiji has little money and no future prospects of his own, he is unable to return what his colleague borrowed. Faced with massive financial burdens, Kaiji is given an offer to board the illustrious Espoir—it is said that one night aboard the ship, and all of your debts will be paid. What seems like a simple night of gambling quickly turns into a game of strategy and betrayal. With the losers of the tournament being subjected to a backbreaking life of indebted servitude, Kaiji must choose his actions—and allies—carefully. However, this is only the beginning of a series of gambles that will wager Kaiji's life, testing the full extent of his wits and will to survive.

Though her trip to Okinawa was supposed to be a lovely excursion to the seaside, college student Kaori Sawahara finds that it is anything but when a horrifying menace emerges from the watery depths. A strange mechanism has taken control of the sea creatures, granting them legs and sending them on land to attack anything in their way. Kaori and her friends—the lustful Erika and the reserved Aki—find themselves caught up in this onslaught, made worse by the creatures' rotting stench of death. Surviving the first assault, Kaori tries to contact her fiancé Tadashi in Tokyo. However, the call is cut short in what sounds like another fish attack. Fearing for his safety, Kaori leaves for Tokyo. With Erika and Aki contending with the attacks in Okinawa, Kaori rushes to find Tadashi, unaware that the crisis has only just begun.

Born from a cocoon in the village of Old Home, a young Haibane—a being with a halo and small gray wings—awakens to a world she does not understand without memories of her past. Named Rakka for the dream of falling she had while inside the cocoon, she soon becomes accustomed to life in the strange town. However, there are strict rules for the Haibane, such as being forbidden to leave the village or go near the walls surrounding it. These, along with mysterious disappearances of their kind on their Day of Flight, begin to unsettle Rakka and the others since they know almost nothing about their own kind. As Rakka and the other Haibane live their lives with no memories of the past, they try to break free from their former pain and ultimately find salvation.