Gorou Honda, a little boy obsessed with baseball, has always admired his father, Shigeharu. Wishing to follow in his father's footsteps, Gorou dreams of becoming a professional baseball player. In turn, his son's starry-eyed admiration encourages Shigeharu to keep persevering, despite his late wife's death and his unsatisfying position on the second-string team Blue Ocean. Unfortunately, an elbow injury forces Shigeharu off the team, and he falls into despair. However, after an offhand joke from his childhood friend, Shigeharu reevaluates his choices and decides to keep playing, leaving behind his prime position as pitcher and taking up the bat. Now motivated more than ever, Gorou works hard to carve his way in the Japanese Little League.

Nasa Yuzaki is determined to leave his name in the history books. Ranking first in the national mock exam and aiming for a distinguished high school, he is certain that he has his whole life mapped out. However, fate is a fickle mistress. On his way home one snowy evening, Nasa's eyes fall upon a peerless beauty across the street. Bewitched, Nasa tries to approach her—only to get blindsided by an oncoming truck. Thankfully, his life is spared due to the girl's swift action. Bleeding by the side of an ambulance, he watches as the girl walks away under the moonlight—reminiscent of Princess Kaguya leaving for the moon. Refusing to let this chance meeting end, he forces his crippled body to chase after her and asks her out. Surprised by his foolhardiness and pure resolve, the girl accepts his confession under a single condition: they can only be together if he marries her!

Chiyo Sakura is a cheerful high school girl who has fallen head over heels for the oblivious Umetarou Nozaki. Much to Chiyo's confusion, when she confesses to her beloved Nozaki, he hands her an unfamiliar autograph. As it turns out, the stoic teenage boy is actually a respected shoujo manga artist, publishing under the pen name Sakiko Yumeno! A series of misunderstandings leads to Chiyo becoming one of Nozaki's manga assistants. Throughout the hilarious events that ensue, she befriends many of her quirky schoolmates, including her seemingly shameless fellow assistant, Mikoto Mikoshiba, and the Prince of the School, Yuu Kashima. Gekkan Shoujo Nozaki-kun follows Chiyo as she strives to help Nozaki with his manga and hopes that he will eventually notice her feelings.

In the town of Clock Hill, there is an old boarding house called Maison Ikkoku. While the residence itself is fairly normal, most of its occupants are not. Yuusaku Godai, its most quiet tenant, has finally reached his limit with his neighbors' constant disruptions and boisterous partying. Wanting a calmer place to call home so that he can study in peace, he prepares to move away. However, his plans to leave are suddenly interrupted when he meets the new boarding house manager, Kyoko Otonashi. Falling madly in love with her, he decides that the boarding house may not be such a bad place to live after all. Unfortunately for him, Kyoko has her own romantic troubles: she is a widow whose husband died six months into their marriage. And despite her blossoming feelings for Godai, Kyoko still cherishes her dearly departed husband, and she believes that no other man could possibly fill the void in her heart. But with Godai's persistence and some help of the other eccentric tenants, she may experience true love once again.