Arsene Lupin III discovers that the spoils from his latest casino robbery are actually Gothic Bills, legendary counterfeits that are nigh impossible to distinguish from genuine bills. Together with colleague Daisuke Jigen, he heads to the small nation of Cagliostro to investigate the origin of these counterfeits. Upon arrival, they save a girl from a high-speed chase who turns out to be Clarisse d' Cagliostro, the daughter of the late Duke d' Cagliostro. She is running from a sinister plot by Count Cagliostro to steal her family's treasure through a forced marriage. Natural flirt Lupin dislikes seeing a girl in distress and seeks to remedy the situation. Goemon Ishikawa XIII, Fujiko Mine, and Kouichi Zenigata also join the fray, each with their own motivations. As everyone converges at Cagliostro Castle, Lupin reminisces about his visit there 10 years ago, and the castle's secrets emerge from the depths.

Although her name means snow white, Shirayuki is a cheerful, red-haired girl living in the country of Tanbarun who works diligently as an apothecary at her herbal shop. Her life changes drastically when she is noticed by the silly prince of Tanbarun, Prince Raji, who then tries to force her to become his concubine. Unwilling to give up her freedom, Shirayuki cuts her long red hair and escapes into the forest, where she is rescued from Raji by Zen Wistalia, the second prince of a neighboring country, and his two aides. Hoping to repay her debt to the trio someday, Shirayuki sets her sights on pursuing a career as the court herbalist in Zen's country, Clarines. Akagami no Shirayuki-hime depicts Shirayuki's journey toward a new life at the royal palace of Clarines, as well as Zen's endeavor to become a prince worthy of his title. As loyal friendships are forged and deadly enemies formed, Shirayuki and Zen slowly learn to support each other as they walk their own paths.

While most young girls make an effort to show off their feminine charms, Futaba Yoshioka deliberately behaves like she wants to repel anyone who might be attracted to her. Ostracized by her female classmates in middle school for being a little too popular with the boys, she desperately strives to avoid a similar situation in high school by being unnecessarily noisy and graceless. Nevertheless, scattered among Futaba's unpleasant memories are the treasured moments with the boy she had a crush on, Kou Tanaka. Unfortunately, that spell abruptly ended on a sour note when he suddenly stopped attending school and never came back. When Futaba finds out that Kou has returned—with a different last name this time—she can already feel the butterflies in her stomach. However, Kou Mabuchi is not the warm boy that she remembers from her days in middle school; he is now taller, more charismatic and withdrawn—making him far less approachable. Futaba believes that if she returns to her former self, Kou will begin to take notice of her again. But is she prepared to sacrifice her bubble of normalcy and risk losing her friends in the process?

Dandy is a groovy, pompadour-wearing man who explores the stars in search of strange aliens for money, desiring to visit his favorite place: BooBies, the best diner in all the cosmos. Traversing the galaxies in his trusty ship, the Aloha Oe, Dandy is accompanied by his two equally unique friends: QT, the vacuum cleaner robot; and Meow, an alien with a cat-like appearance. Although exciting, Dandy's job is never simple, and each new day promises a completely different, thrilling adventure. Together, Dandy and his crew get dragged into perilous journeys, misadventures in romance, and out of this world scenarios—all whilst steering clear of the evil scientist, Dr. Gel of the Gogol Empire.