After years of conflict, humans and monsters have settled their differences and are now at peace. This post-war era led to the foundation of Lindworm—a town which has since become the focal point of racial harmony. As a human doctor specializing in monster biology, Glenn Litbeit runs a small clinic alongside his partner, Saphentite Neikes, who is a half-snake monster known as a lamia. He uses his knowledge to tend to any monsters who seek his aid. Whatever affliction, concern, or injury it may be, he will always be there, ready to help.

Because of the constantly declining birth rates over many decades, human civilization is all but extinct. With only a few humans remaining, they survive in this post-apocalyptic world with what was left behind by the previous generations. Earth is now dominated by fairies, tiny creatures with extremely advanced technology, an obsession with candy, and a complete disregard for human safety. A young girl who has just finished her studies returns to her hometown and is designated as an official United Nations arbitrator. Her duty is to serve as a link between mankind and fairies, reassuring each side that both races can live together peacefully. She imagines this task will be easy enough, but controlling the disasters created by the oblivious fairies in their pursuit of candy will require a lot more effort than she initially believes.

The majority of the Matsuno household is comprised of six identical siblings: self-centered leader Osomatsu, manly Karamatsu, voice of reason Choromatsu, cynical Ichimatsu, hyperactive Juushimatsu, and lovable Todomatsu. Despite each one of them being over the age of 20, they are incredibly lazy and have absolutely no motivation to get a job, choosing to live as NEETs instead. In the rare occurrence that they try to look for employment and are somehow able to land an interview, their unique personalities generally lead to their swift rejection. From trying to pick up girlfriends to finding the perfect job, the daily activities of the Matsuno brothers are never dull as they go on all sorts of crazy, and often downright bizarre, adventures. Though they desperately search for a way to improve their social standing, it won't be possible if they can't survive the various challenges that come with being sextuplets!

Animation studio Gainax presented a website for the release of a movie adaptation of the Tengen Toppa Gurren Lagann TV series in the fall of 2008. Both the original director and series script editor will return to work on the new project. Gainax will also be hosting four events to celebrate this occasion at this year's Tokyo International Anime Fair, featuring voice actors from the anime.