Much like the other students at her school, first-year student Saki Aoi finds herself captivated by the beauty of her senior on the school board, Makoto Hanaoka. While she worries that Hanaoka would be uncomfortable receiving a confession from another girl, Aoi musters up the courage to tell her anyway. However, Hanaoka's response surprises Aoi for a completely different reason—Hanaoka is actually a cross-dressing boy! Fully expecting Aoi to be abhorred by this revelation, Hanaoka is shocked to find that she has no issues with it. Though Hanaoka rejects Aoi's request to go out with her—citing his identity and the fact that he has never fallen in love before—Aoi insists that she will become his first love. Taken aback by Aoi's determination, Hanaoka wonders if he can really fall in love with her if he cannot find it in him to truly love himself first.

Jougorou Kobato has a habit of inserting himself into other people's problems. After realizing his detective skills are neither wanted nor appreciated, he makes an agreement with his shy friend Yuki Osanai to become ordinary together. Now entering high school, they aim to be perceived as regular people, yet Kobato cannot help but fall back into his deductive ways when faced with everyday mysteries. Unfortunately, mundane occurrences are not all the duo stumbles across. As they go through their school days trying to avoid drawing attention to themselves, Kobato and Osanai at times get caught up in incidents that put their plan of a peaceful, average life at risk.

Under the tutelage of the great demon warlock Romberg, Ike grew up with knowledge regarding an ancient advanced civilization that once ruled the land. Coupled with his innate talent in magical arts, this upbringing allows Ike to quickly rise in the Demon Lord's army ranks, leading his brigade to consecutive victories against humans. However, Ike has a secret—he is a human himself. Despite knowing all too well the consequences if this information is ever to leak, Ike is willing to face such immense danger to achieve his goal: find a way for humans and demons to coexist and stop the war that has been carried on for far too long.

Hoping for a fresh start, househusband Masaki Fujiyoshi, his spouse Hiromu, and their toddler son, Hikari, move to a new neighborhood. The couple's union was frowned upon by many due to Masaki's status as an omega—a secondary gender that allows an individual to give birth. Even for an alpha—seen as the superior secondary gender—such as Hiromu, discrimination seems to be commonplace and a hindrance to a life of domestic bliss. Fortunately, the new family is not alone. Little Hikari becomes attached to Yuuki Hirai, the Fujiyoshis' lonely college student neighbor. Despite his initial reluctance, Yuuki ends up befriending the infant. Moreover, the family can also confide in Hiromu's childhood friend and coworker Tomohiro Matsu Matsuo. Although everything is going well for the young couple and their child, a sudden presence from the past might pose a problem for the peaceful life they dream of.