Self-professed home security guard Mahiro Oyama has not left his home in years, secluding himself in his room playing erotic visual novels. This depraved lifestyle causes his prodigious sister, Mihari, to worry about his well-being. In hopes of solving this problem, she devises a plan to rehabilitate him back to normalcy. The first part of Mihari's plan is to concoct a medicine that changes her brother's biological constitution into a bona fide female, much to Mahiro's vehement dismay. Stuck in this predicament, Mahiro has no choice but to live out his life as a cute girl until the effect wears off—if it ever does.

The stray cat Tsushima is adopted by an old lady—mistakenly referred to as Ojii-chan—who dreamed of owning a cat resembling a bear. The talking cat makes life both colorful and more exhausting for the poor old lady and her numerous other cats. These Ore, Tsushima shorts depict the everyday exploits of the sluggish leopard cat Tsushima.

Zhuge Kongming earned a reputation as one of the greatest tacticians of the Three Kingdoms period of third-century China. Having led his army through countless grueling victories, Kongming falls gravely ill during the Battle of Wuzhang Plains. The weariness and regret stemming from the seemingly never-ending war catch up to him, and as he draws his final breath, Kongming wishes that if he were to reincarnate, he would be reborn in a more peaceful era. His wish comes true, and Kongming wakes up in modern-day Tokyo with a younger body and his memories intact. Thrust into an unfamiliar world, he finds his way into a nightclub and meets Eiko Tsukimi, an aspiring singer whose performance immediately captivates him. Pitying his confusion, Eiko takes Kongming under her wing and teaches him about the current world, which leads to Kongming's interest in contemporary music. Seeing Eiko's immense musical potential, Kongming vows to make the world recognize her and soon takes on the role of her manager. Unsurprisingly, the music industry is unforgiving to those who make even the slightest mistakes. Still, Kongming is determined to accomplish his goals—even if he must utilize the war stratagems he famously used in his previous life!

An apocalyptic event has ravaged Japan, leaving nothing but endless sandy plains behind, and a strange rusting disease terrorizes the remnants of civilization. According to the government, the horrific state of the new world is the result of mushroom spores being spread by the likes of Bisco Akaboshi, labeled the Man-Eating Mushroom. But Bisco would beg to differ. In reality, he is a Mushroom Protector, determined to uncover the legendary Sabikui mushroom—said to be the ultimate cure for the rusting disease. Joining him on his quest are his giant crab Akutagawa and the kind doctor Milo Nekoyanagi, who is actively searching for a rust poisoning treatment for his sick sister. Despite the prejudice aimed toward him by the common folk, Bisco refuses to give up on his quest to purify the rotting world.