Ever since childhood, Scarlet El Vandimion has preferred to deal with wrongdoers by using her fists. However, to preserve her family's image, she suppresses her instincts and tolerates the abuse inflicted by her childish fiancé, Second Prince Kyle Von Pallistan. Only Kyle's brother, First Prince Julius, is aware that there is more to Scarlet than meets the eye, but she cares little about his growing interest. In the middle of a ball, Kyle accuses Scarlet of harassing Terenezza Hopkins, a commoner that has taken his heart. Scarlet's engagement to Kyle is nullified, leaving her outraged that all of her efforts to endure thus far have amounted to nothing. Scarlet dons her studded leather gloves, once again becoming the Mad Dog Princess. Joined by Julius and werebeast Nanaka, Scarlet is ready to give filthy nobles a taste of their own medicine—one punch at a time.

For as long as he can remember, the klutzy Tsuyoshi Yano has been prone to injury. Constantly showing up to school with fresh scrapes and bruises, he has long become accustomed to the pain and to the sight of his face covered in bandages. However, Yano's days begin to change for the better when he is transferred to a new class and meets Kiyoko Yoshida, the class president known for her reliability and kindheartedness. Through Yoshida's efforts to learn more about him, Yano starts to experience the kind of high school life he has always wished for—one filled with laughter and camaraderie. Between casual conversations and countless small accidents, the two gradually grow closer, and their relationship may bloom into something more than just friendship.

After surviving the entrance exams, Sakuta Azusagawa has finally enrolled in the same university as his girlfriend, Mai Sakurajima. He is gradually getting used to the unfamiliar environment as he attends student gatherings and makes new acquaintances. Everything seems to be going smoothly until Sakuta's friend and Sweet Bullet idol group member Uzuki Hirokawa begins acting out. With fellow Sweet Bullet member Nodoka Toyohama pleading for his help, Sakuta realizes that he has stumbled upon another case of the inexplicable Puberty Syndrome—Uzuki is feeling pressured by the sudden surge of popularity and rumors of a potential solo career. While Sakuta searches for a solution, another occurrence of Puberty Syndrome gradually emerges from the shadows.

When university students Kuriaki Magi and Yaeko Kirihara witness a man receive a fatal blow to the head, they can barely believe it when he flees the scene unscathed. Once they catch up to the victim, Momoyuki Mogura, they learn that he is immortal. While Magi and Yaeko initially presume Mogura is delusional, their opinion of him changes as they begin seeing apparitions. As Mogura explains, those are spirits of dead people that produce demon fire, a light that guides the spirits after death. Stripped of the right to carry the fire, Mogura has spent years collecting the products from spirits, hoping to one day enter the afterlife. With Magi and Yaeko now helping him find more spirits, the mysterious Mogura may finally achieve his peculiar dream.