Aside from her deep passion for eating cakes, the clumsy Ichigo Amano has never been successful at anything. After an encounter with Henri Lucas, a famous patissier, Ichigo's amazing tasting abilities—although unbeknownst to her—are discovered. Recognizing her talent, Henri offers her the chance to attend St. Marie Academy, a prestigious culinary school which specializes in desserts. In spite of the fact that she is a beginner lacking skills, thanks to Henri's recommendation, Ichigo is placed in the topmost group with the Sweets Princes. The princes, famous throughout the school for their magical treats, are Sennosuke Andou, an expert in traditional Japanese sweets; Satsuki Hanabusa, with a flair for candied flowers; and Makoto Kashino, a gifted chocolatier. Ichigo and the Sweets Princes, each accompanied by their Sweets Spirits—fairies who make patissiers' dreams come true—all work towards their goals in the competitive world of sweets.

The girls of the Amusement Club return in Yuru Yuri♪♪, finding new ways to make passing time even more enjoyable. Their members consist of the always energetic Kyouko Toshinou; calm and sensible Yui Funami; polite but often overlooked Akari Akaza; and Chinatsu Yoshikawa, who stumbled upon the others while looking for the Tea Ceremony Club. Together they are the Amusement Club, which has the deceptively simple task of keeping its members entertained. Along with the Student Council and the odd family member, they strive to enjoy their youth to the fullest. Whether it's a trip to a hot spring or finishing overdue homework, their lives are never dull, and they will always find an excuse to spend time together.

Yurume, an 18-year-old ronin and recent high school graduate, has high hopes of being accepted and attending Tokyo University. She moves into an apartment complex, the Maison du Wish, located on the outskirts of Tokyo where other ronins living there are studying for upcoming college acceptance exams.

The continuation of Yurumates 3D right after the first season.