Naoya Mukai's crazy lifestyle of balancing his time between both of his girlfriends, Saki Saki and Nagisa Minase, is still as hectic as ever. Additionally, the blonde bombshell Rika Hoshizaki also has her sights on Naoya, complicating his already convoluted love life. As if things could not get more ridiculous, another girl inserts herself into the situation: Shino Kiryuu, who is determined to end Naoya's two-timing and ensure Saki's happiness. However, Shino harbors secret feelings for Naoya—a longing she believes she must forsake—yet simply cannot due to the deep attraction he inspires.

Due to poor finances, an epidemic, and famine, the once prosperous Tearmoon Empire ultimately falls to a revolution instigated by its citizens and supported by neighboring nations. The rebellion also brings dire consequences for Mia Luna Tearmoon, the empire's extremely spoiled princess, who endures three years in the dungeons before facing execution. By some miracle, Mia finds herself reincarnated as her 12-year-old self, retaining full memories of everything that had transpired. With the pain of the guillotine blade freshly imprinted on her neck, Mia is determined to use this second chance at life to avoid the grim fate that awaits her. She utilizes all her knowledge to improve the state of the kingdom and gather personal allies, inadvertently winning over the people's hearts and becoming beloved as a saint.

With the conclusion of her favorite romance manga, Fuuko Izumo is ready to end her life of misery and loneliness having long accepted her fate of never being able to experience passionate love like fictional characters. Cursed with unluck, anyone Fuuko touches is in grave danger of experiencing unimaginable calamity. While the possibility of imminent danger would have most sane people run in the opposite direction, Undead has other ideas. He is an immortal being with superhuman regenerative powers desperately seeking death, which has always eluded him. When their paths finally cross, Undead sees an opportunity to finally end his suffering by using Fuuko's unluck. But before Undead can unlock the full potential of Fuuko's power to trigger the final devastating blow, the duo must first fend off a murderous secret organization hell-bent on exterminating those with special abilities.

After succeeding in their winter conflict against Taiju Shiba and his Black Dragons, the Tokyo Manji Gang absorbs their group's remaining members. Due to his heroic courage and indomitable spirit, Takemichi Hanagaki should have accomplished his goal of defeating the tragic fate awaiting his girlfriend, Hinata Tachibana. In reality, Takemichi's troubles are far from over. Although Takemichi's actions have exposed Tetta Kisaki's treachery, the conniving schemer has found power elsewhere: Tenjiku, a dangerous gang led by the enigmatic Izana Kurokawa. Izana sets his sights on Manjirou Mikey Sano, pursuing a vicious interest in the Tokyo Manji Gang's aloof leader. In the future, Takemichi discovers that the machinations of Izana and Kisaki led to Mikey's moral ruin—a downfall that directly results in Hinata's death. Unfortunately, a terrible loss robs Takemichi of his time-leaping ability, stranding him in the past with one final chance to rescue everyone he loves.