The spirited Boruto Uzumaki, son of Seventh Hokage Naruto, is a skilled ninja who possesses the same brashness and passion his father once had. However, the constant absence of his father, who is busy with his Hokage duties, puts a damper on Boruto's fire. Upon learning that his father will watch the aspiring ninjas who will participate in the upcoming Chunin exams, Boruto is driven to prove to him that he is worthy of his attention. In order to do so, he enlists the help of Naruto's childhood friend and rival, Sasuke Uchiha. The Chunin exams begin and progress smoothly, until suddenly, the Konohagakure is attacked by a new foe that threatens the long-standing peace of the village. Now facing real danger, Naruto and his comrades must work together to protect the future of their cherished home and defeat the evil that terrorizes their world. As this battle ensues, Boruto comes to realize the struggles his father once experienced—and what it truly means to be a ninja.

Following the successful end of the Fourth Shinobi World War, Konohagakure has been enjoying a period of peace, prosperity, and extraordinary technological advancement. This is all due to the efforts of the Allied Shinobi Forces and the village's Seventh Hokage, Naruto Uzumaki. Now resembling a modern metropolis, Konohagakure has changed, particularly the life of a shinobi. Under the watchful eye of Naruto and his old comrades, a new generation of shinobi has stepped up to learn the ways of the ninja. Boruto Uzumaki is often the center of attention as the son of the Seventh Hokage. Despite having inherited Naruto's boisterous and stubborn demeanor, Boruto is considered a prodigy and is able to unleash his potential with the help of supportive friends and family. Unfortunately, this has only worsened his arrogance and his desire to surpass Naruto which, along with his father's busy lifestyle, has strained their relationship. However, a sinister force brewing within the village may threaten Boruto's carefree life. New friends and familiar faces join Boruto as a new story begins.

Although citizens of London view dragons as a fairy-tale myth, statistics confirm that 72% of the city's deaths are caused by these grotesque beings. Unable to see them, the public is oblivious to their existence. However, in a mirror dimension to Front London, exists a place where dragons can be seen with the naked eye—Reverse London. Ninny Spangcole is a member of a popular girl group. But in Reverse London, she works as a Witch at Wing Bind—an organization that dispatches agents to exterminate the beasts and protect the citizens of both Londons using magic. Ninny and her partner, Noel Niihashi, in addition to their jobs, safeguard Baldo Ywain Parks, a young man with an odd connection to the dragons. Thanks to the Wing Bind's hard work, there were no fatal dragon attacks for almost a century. But the peace shatters when Baldo's presence unexpectedly causes a Dark Dragon to wreak havoc in the city. The witches are further inconvenienced when Ninny's troublesome former bandmate appears in Reverse London—in tandem with another powerful dragon.

The story begins when high school student Kazuki Muto is killed one night saving a mysterious girl from a monster, only to wake up in his school dorm, believing it to have been a dream; however, he soon finds out that dream wasn't a dream at all when a giant serpentine monster attacks him and his sister. Tokiko Tsumura, the girl he saved, explains that the monster is a homunculus. Kazuki had been attacked and killed by it when he was rescuing her; however, she, feeling responsible for him, revived him by placing a Kakugane medallion in his chest, serving as a replacement heart. The Kakugane, as Tokiko explains, is an alchemical device that, when activated, takes a certain form based on the Kakugane's user, forming a unique Buso Renkin. The Buso Renkin is the only thing that can destroy a homunculus monster. Using this, Kazuki creates his own Buso Renkin (the Sunlight Heart, a huge lance). Along with Tokiko and her own Buso Renkin (the Valkyrie Skirt, an execution scythe), Kazuki joins the fight against the homunculi and their master.