Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.

Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

At the renowned Shuchiin Academy, Miyuki Shirogane and Kaguya Shinomiya are the student body's top representatives. Ranked the top student in the nation and respected by peers and mentors alike, Miyuki serves as the student council president. Alongside him, the vice president Kaguya—eldest daughter of the wealthy Shinomiya family—excels in every field imaginable. They are the envy of the entire student body, regarded as the perfect couple. However, despite both having already developed feelings for the other, neither are willing to admit them. The first to confess loses, will be looked down upon, and will be considered the lesser. With their honor and pride at stake, Miyuki and Kaguya are both equally determined to be the one to emerge victorious on the battlefield of love!

Every Thursday, Shuchiin Academy student council secretary Yuu Ishigami can be found in a state of anxiety. He counts down the hours until he can escape to the student council chamber to read the latest chapter of the popular seinen manga series, Momo Doesn't Think. Joining Ishigami in his weekly reading, student council president Miyuki Shirogane swiftly grows excited at the news of a third season of the manga's anime adaptation. However, it is only a matter of time before vice president Kaguya Shinomiya discovers what has been engrossing the two boys. With the stigma of being labeled an otaku looming over his head, Shirogane must do everything he can to keep his embarrassing secret from coming to light.