Former ace runner of Sendai Josei High School, Kakeru Kurahara is chased away from a convenience store for shoplifting. Shaking off his pursuer, he runs into Haiji Kiyose, another student from his university. Haiji is impressed by Kakeru's agility and persuades him to live in Chikusei-sou, the run-down apartment where Haiji resides along with eight other students. Having lost his entire apartment deposit at a mahjong parlor, Kakeru accepts the offer reluctantly. However, Haiji reveals a secret during Kakeru's welcoming party: the apartment is actually the dormitory of the Kansei University Track Club. He unveils his ultimate goal of participating in the Hakone Ekiden—one of the most prominent university marathon relay races in Japan. Unfortunately, all the residents apart from Haiji and Kakeru are complete running novices. Worse still, none of the inhabitants are even remotely interested in being involved with Haiji's ridiculous plan! With only months before the deadline, will the fourth-year student be able to convince them otherwise and realize his elusive dream of running in the Hakone Ekiden?

Yuu Izumi leads a high school life filled with one mishap after another. No matter how improbable the situation, unfortunate events strike him at every turn. In possession of such terrible luck, Izumi enters his second year with a single wish in mind—to spend more time with his affectionate girlfriend, Micchon Shikimori. Cute, athletic, and caring, Shikimori is immensely popular at their school. But since they began dating a year ago, Izumi has witnessed a surprising side to his otherwise adorable girlfriend: when the need arises, she turns incredibly cool! His misfortunes are easily avoided when she is there to protect him with an awe-inspiring look on her face. Charming in every way, she never ceases to make his heart skip a beat. Unfortunate as he may be, Izumi is sure to see his days of bad luck end thanks to the cute yet cool Shikimori.

In 1863, Izuminokami Kanesada and his partner, Horikawa Kunihiro, arrive in the streets of Edo from the future to investigate their master's reports of an upcoming enemy invasion. As humanoid manifestations of the famous Toshizou Hijikata's swords, they have been tasked with protecting history from the Retrograde Army that seeks to alter it. Soon enlisting the help of other sword warriors, they continuously battle the mysterious army throughout the Bakumatsu period. However, their journey will not be an easy one. Fraught with blood and betrayal in the chaotic era closest to their hearts, the duo will be forced to make difficult decisions with everything they care about on the line.

The story begins in a small town, Pennsylvania in 1838. Jeanie MacDowell is a cheerful and beautiful girl with light brown hair. Jeanie enjoys playing the piano and loves taking piano lessons from her mother. Steven, a good harmonica player, and Bill, a black boy who is very good at playing the banjo, are great friends of Jeanie's. They enjoy playing music together like a small band. However, Jeanie's happy life changes dramatically after her mother suddenly passes away. Experiencing many difficulties and learning the importance of life, she decides to devote her life to helping many people suffering from illness. This series is a highly emotional love story about the relationship between young Stephen Foster, who later becomes a famous composer and author of children's songs, and young Jeanie MacDowell, who becomes Stephen Foster's wife.