Nestled away on the rooftop of Tenikai General Hospital is the unconventional Department of Investigative Pathology headed by the eccentric Dr. Takao Ameku. The tiny department, consisting of Takao and her sole resident Yuu Kotori Takanashi, treats complex cases that most other departments within the hospital cannot resolve on their own. The mystery-obsessed Takao always tries to insert herself into cases that capture her fancy—much to the dismay of her colleagues and the police. Even if her meddling creates more problems for the hospital and those around her, none can deny the brilliance that the young department head exhibits as she weaves a diagnosis together. No matter the specialty, no case is impossible for Takao and a somewhat reluctant Takanashi to solve.

After years of animosity, the leaders of Osaka's Somei and Tokyo's Miyama yakuza groups have called a truce—by arranging an engagement between their respective grandchildren, Yoshino Somei and Kirishima Miyama. To this end, 17-year-old Yoshino moves to Tokyo to live with the Miyama family and attend school with her new fiancé. Although Kirishima is all smiles and perfectly polite, there is something unsettling about his demeanor that Yoshino cannot put her finger on. Yoshino's suspicions are soon confirmed: despite his manners, Kirishima is a masochistic maniac. He hurts people without batting an eye and also revels in being punished verbally and physically himself. What he wants most is a spoiled and arrogant fiancée who will ruin his life. When Yoshino does not quite meet his expectations, he reveals his true colors and openly insults her. However, instead of running away in fear, Yoshino decides to take revenge by making Kirishima fall in love with her and then ruthlessly breaking his heart.

Ever since Rakurou Sunraku Hizutome started to play the extremely popular virtual reality game Shangri-La Frontier, he has truly fallen in love with it. Sunraku has quickly made a big name for himself by fighting two of the seven unique, nearly unbeatable monsters, which is unthinkable for most players. To progress the game's story, he sets out on an adventure with his leporine guide, Emul, to acquire a magic operation unit from an ancient workshop. Though Sunraku breezes through this quest alongside his clanmates Towa Arthur Pencilgon Amane and Kei OiKatzo Uomi, there seems to be an ulterior motive as to why the two of them decided to help Sunraku in the first place. Nevertheless, Sunraku gains valuable knowledge and allies, critical for his advancement in the game. By seeking out powerful enemies and unraveling the inner workings of the game's world, Sunraku may just change Shangri-La Frontier forever.

Second season of Jibaku Shounen Hanako-kun.