Every day, a young girl wearing a mask stands by the beach and sings a nostalgic melody. After experiencing two sudden heart-wrenching partings when she was only a child, Nino Arisugawa has been singing her songs to the ocean, bound by a promise made with her two childhood friends—her first love, Momo Sakaki, and a boy who composed music, Kanade Yuzu Yuzuriha. Having never met each other, the boys both individually promised that if Nino was ever separated from them, her voice would be the beacon to reunite them once again. After six long years, destiny has finally placed Nino, Momo, and Yuzu in the same high school. However, the passage of time has changed many things in their lives—while Nino relentlessly attempts to fulfill her childhood promise with the boys, Yuzu's feelings for her from the past resurface, and Momo goes to great lengths to prevent a reunion with Nino. Through music, will they be able to mend their friendship and overcome all the feelings involved in this complicated love triangle?

Daisuke Kanbe, a man of extraordinary wealth, is assigned to the Modern Crime Prevention Headquarters as a detective. It is there that he gets partnered with Haru Katou, a humane detective who values justice above all. The two are polar opposites, and their morals clash time and time again. Haru despises Daisuke for using monetary wealth to solve cases, as he believes that money isn't everything. The two will have to combine their efforts, however, to solve the mysteries that are coming their way.

The start of Hanae Ashiya's high school career has not been easy—he has spent all of the first week in the infirmary, and his inexplicable condition is only getting worse. The cause of his torment is the mysterious fuzzy creature that has attached itself to him ever since he stumbled upon it the day before school began. As his health continues to decline and the creature grows in size, Hanae comes across a flyer advertising an exorcist who expels youkai. Desperate and with nothing left to lose, he calls the number and is led to the Mononokean, a tea room which suddenly appears next to the infirmary. A morose-sounding man, Haruitsuki Abeno, reluctantly helps Hanae but demands payment afterward. Much to Hanae's dismay, he cannot afford the fee and must become an employee at the Mononokean to work off his debt. And to make things worse, his new boss is actually one of his classmates. If Hanae ever hopes to settle his debt, he must work together with Abeno to guide a variety of dangerous, strange, and interesting youkai back to the Underworld.

Sergeant Sousuke Sagara returns to Jindai High School to protect the precious war asset, Kaname Chidori, from any threat. However, his lack of social skills and real-life experience result in comical yet dangerous situations, endangering the peaceful school life Kaname longs for. As Sousuke continues to bring a wide range of weapons to school as a means to solve threats—real or fake—Kaname struggles to fulfill her duty as the student council vice president all while keeping him in check. To ensure a successful mission, Sousuke is occasionally forced to use the costume of a famous amusement park mascot called Bonta-kun. With his technical expertise, he eventually transforms the exuberant uniform into a cutting-edge exoskeleton that has only one dysfunction: the voice translator can only produce the sound mofu. Full Metal Panic? Fumoffu depicts the adventures of Kaname and Sousuke as they try to live their normal school lives despite the chaos they inadvertently cause.