Suehara Maru is childhood best friends with one of Hozumino High School's most popular girls, Kuroha Shida. Cute, outgoing, and affectionate, Kuroha is the perfect older sister type. She has boys constantly begging at her feet to be with her. Yet, when she confesses to Suehara one day, he immediately rejects her; he just can't think of her in that way! Besides, he already has his sights set on his first love—school idol and renowned author Shirokusa Kachi. Suehara believes that he has a chance with Kachi after one fateful meeting, but soon, he finds out that Kachi has a boyfriend! With his dreams now shattered, Suehara agonizes over what could have been. That is, until Kuroha approaches him with a proposal: let's get revenge.

Seeking the key to the elixir of immortality, the group arrives at the fortress of the island's monstrous ruler, the Tensen. To survive and escape the island, cooperation becomes essential—regardless of whether one is a condemned criminal or an executioner. Meanwhile, the shogunate orders additional landings on the island of the Immortal Realm, led by Shugen Yamada Asayemon. Among them are the Ishigakure clan, who share a past with Gabimaru. Desperate to find the elixir and escape the island, Gabimaru and his companions face the Tensen in a battle that escalates into an all-out confrontation between humans and immortals! (Source: Twin Engine, edited)

Having been accepted into the Kaede Inn, Nana struggles to find some way to contribute, though she inadvertently brings more trouble than assistance. However, Nana's worries are directed more towards fellow resident Nyu, whom she had only known as Lucy, the violent Diclonius. Fearful that Nyu will unleash the same horrific savagery—violence that scars Nana to this day—upon those close to her, Nana faces a dilemma: attempt to live peacefully alongside Lucy with all the uncertainty that that entails or dispose of the source of her worries, shattering the relationships she has formed at the inn. As Nana struggles to come to a decision, Nyu recalls a painful memory of one of her dearest friends and one of her greatest rivals.

The search for the remains of Emperor Gaz continues. Chaika still in search of knowing who she really is and what her purpose is. Similarly, the Red Chaika continues the search for the rest of Emperor Gaz's remains. The Gillette corporation continues the mission to catch every last Chaika. In their adventure they give a revealing account kept secret by the Emperor, which Chaika, Fredrica, Toru, and Akari decide to uncover. (Source: ANN, edited)