Yuuki Aito is a perverted manga artist who appreciates panties, wishing to draw as many as he can. Being surrounded by numerous female assistants, he is constantly asking to use them as references for the manga he draws. Although Aito has an extremely degenerate mind, he can also be a very kind, generous, and helpful person. The duality of his behavior confuses his assistants—do they love the considerate side of him that he rarely displays, or do they hate him for the perverted thoughts he has most of the time?

Mizuki Usami is a passionate member of her school's art club, but the club has a problem—Usami is the only member who takes her craft seriously! The lazy club president constantly sleeps through activities and Collette hasn't regularly attended club activities in quite some time. Uchimaki Subaru, despite being an exceptional artist who could win an award if he tried, is obsessed with drawing the perfect 2D wife. Light-hearted and comedic in tone, Kono Bijutsubu ni wa Mondai ga Aru! follows Usami as she struggles to do art club-like activities, often obstructed by her motley crew of good-for-nothings and her distracting crush on Subaru.

Yuuta Hibiki wakes up in the room of Rikka Takarada and notices two things: he has no memories, and he can hear a mysterious voice calling his name from a nearby room. On further inspection, he finds a robot—which introduces itself as Hyper Agent Gridman—behind the screen of an old computer. Much to Yuuta's surprise, Rikka cannot hear Gridman, nor can she see the ominous monsters looming over a thick fog as it envelopes the town outside. Another giant monster materializes in the city and proceeds to wreak havoc. Amidst the confusion, Yuuta is once again drawn to the old computer and merges with Gridman. Suddenly, he appears in the middle of the battle and is forced to fight the monster. Together with Rikka and fellow classmate Shou Utsumi, Yuuta forms the Gridman Alliance to defeat the monsters plaguing the city and find whoever is responsible for their emergence.

Starting his new term at Tanenashi High School, an unmotivated freshman searches for a club that requires minimal participation to suit his needs. He then comes across the magic clubroom, and inside is a cute upperclassman practicing her magic tricks. Suffering from stage fright that causes her to slip up in her acts, she has a tendency to end up in the most embarrassing situations. Despite having little interest in a club run by an incapable magician, the freshman finds himself involved as a new member, experiencing all sorts of awkward moments with his eccentric mentor.