After fainting at work, a young lady awakens in the back room of the café she works at with no memory of her life or those around her. Two of her friends, whom she soon learns are named Shin and Toma, are called to help her get home safely. Once she is alone, she meets a spectral boy named Orion that only she can see and hear. He explains that she lost her memories because of his chance visit to her world, so he vows to help her remember who she is. However, regaining her departed memories without worrying those around her may be more difficult than she realizes. In addition to the gloomy Shin and the protective Toma, she must be wary of arousing the suspicions of the captivating Ikki, the quick-witted Kent, and a mysterious man who lurks in the distance. As her amnesia entangles her in the lives of each of these men, her fragmented memories return piece by piece, and the mysteries of her circumstances slowly come to light.

First encounters are always memorable because regardless of the outcome, new experiences are sure to happen. For Akira Tsubaki, a young boy who knows next to nothing about girls, and new transfer student Mikoto Urabe, a mysterious girl who wears a cold facade, their first encounter takes a turn for the romantic. Through a series of strange events, Tsubaki suddenly falls in love with Urabe, and together they develop a curious bond. Thus begins the romance and mystery of Urabe, a girl who seems to have a unique way of expressing her emotions.

Just the words I love you, and everything changes—such is the nature of the bittersweet trials of high school romance. Tenma Tsukamoto, a second year, is on a quest to confess her feelings to the boy she likes. Kenji Harima, a delinquent with a sizable reputation, is in a similar situation, as he cannot properly convey his feelings to the one he loves. Between school, friends, rivalries, and hobbies, these two will find that high school romance is no walk in the park, especially as misunderstandings further complicate their plight. School Rumble is a high-octane romantic comedy full of relatable situations, as Tenma and Kenji both try to win the hearts of those they desire.

The story follows the life of Yuu Haruna, who recently moved into Tokyo with his sisters after their father is forced to transfer overseas on work. On his way to buy dinner while looking at his Twitter account, a high school girl suddenly crashes into him. Thinking he was taking upskirt pictures of her, the girl takes Yuu's phone, breaks it, and slaps him before leaving Yuu lying on the ground. As it turns out, this girl—Fuuka Akitsuki—also goes to the school Yuu is transferring to. Unlike most people, Fuuka doesn't own a cellphone; she even listens to music using a CD player. Eventually these two become closer, and decide to form a band with their friends and enter the professional world of music. With Fuuka around, what will now become of Yuu's new life in Tokyo?